Ceftriaxone and Emla drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ceftriaxone (ceftriaxone sodium) and Emla (lidocaine; prilocaine). Common drug interactions include infusion site extravasation among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Ceftriaxone and Emla. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Ceftriaxone?

Ceftriaxone has active ingredients of ceftriaxone sodium. It is often used in typhoid fever. eHealthMe is studying from 40,991 Ceftriaxone users. Check the latest studies of Ceftriaxone.

What is Emla?

Emla has active ingredients of lidocaine; prilocaine. eHealthMe is studying from 5,276 Emla users. Check the latest studies of Emla.

On Jul, 23, 2026

63 people who take Ceftriaxone and Emla together, and have interactions are studied.

What are the common drug interactions of Ceftriaxone and Emla, by gender? *:

female:

Infusion site extravasation (flow of (blood or lymph) from infusion site)
Injection site pain
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Lipase increased
Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Oedema (fluid collection in tissue)
Oedema upper limb (swelling of arm)
Pallor
Pancreatitis (inflammation of pancreas)
Platelet count decreased

male:

Pneumonia
Respiratory distress (difficulty in breathing)
Upper respiratory tract infection
Extubation
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Mastoiditis (infection of mastoid bone)
Mitral valve stenosis (narrowing of mitral valve)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Anaemia (lack of blood)
Haemodynamic instability (disturbances in the blood movement in our body)

What are the common drug interactions of Ceftriaxone and Emla, by age (0-1 to 60+)? *:

0-1:

Feeding disorder neonatal (when newborn refuse to drink milk)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Respiratory alkalosis (elevated blood ph due to excess breathing)
Vomiting
Acquired methaemoglobinaemia (a condition that results in the formation of an abnormal form of haemoglobin)
Methaemoglobinaemia (a disorder characterized by the presence of a higher than normal level of methemoglobin in blood)
Premature baby
Cyanosis neonatal (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails in newborn)
Inflammation
Jaundice acholuric (elevated unconjugated bilirubin that is not excreted by the kidney)

2-9:

Upper respiratory tract infection
Intracranial tumour haemorrhage (bleeding tumour in brain)

10-19:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Endocarditis (inflammation in heart muscle)
Fatigue (feeling of tiredness)
Laryngomalacia (a congenital softening of the tissues of the larynx)
Pericardial effusion (fluid around the heart)
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Respiratory distress (difficulty in breathing)
Respiratory tract oedema (swelling of respiratory tract due to excess fluid collection in tissue)
Streptococcal bacteraemia (a bacterial infection of blood)

20-29:

n/a

30-39:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Bone marrow disorder
Granulocytes maturation arrest (not producing the mature granulocyte)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Rectal haemorrhage (bleeding from anus)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Pulmonary embolism (blockage of the main artery of the lung)

40-49:

Sepsis (a severe blood infection that can lead to organ failure and death)
Cellulitis (infection under the skin)
Cellulitis gangrenous (localized inflammation of the soft or connective tissue with considerable mass of body tissue dies (necrosis))
Gangrene (body tissue dies)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perineal abscess
Urinary tract infection
Vulval abscess
Vulval cellulitis (inflammation of skin around vagina)
Vulvitis (inflammation of the vulva)

50-59:

Febrile neutropenia (fever with reduced white blood cells)

60+:

Sepsis (a severe blood infection that can lead to organ failure and death)
Coma (state of unconsciousness lasting more than six hours)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Dyspnoea (difficult or laboured respiration)
Depressed level of consciousness
Haematocrit decreased
Haemoglobin decreased
Neutropenia (an abnormally low number of neutrophils)
Pneumonia
Pneumonitis (inflammation of the walls of the alveoli in the lungs)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 17 people, 26.98%
Pain: 13 people, 20.63%
Back Pain: 8 people, 12.70%
Cough: 8 people, 12.70%
Hypersensitivity: 7 people, 11.11%
Constipation: 7 people, 11.11%
High Blood Pressure: 6 people, 9.52%
Diarrhea: 6 people, 9.52%
Infection: 6 people, 9.52%
Fever: 6 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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