Ceftriaxone and Linzess drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ceftriaxone (ceftriaxone sodium) and Linzess (linaclotide). Common drug interactions include fatigue among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Ceftriaxone and Linzess. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Ceftriaxone?

Ceftriaxone has active ingredients of ceftriaxone sodium. It is often used in typhoid fever. eHealthMe is studying from 40,991 Ceftriaxone users. Check the latest studies of Ceftriaxone.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

On Jul, 20, 2026

49 people who take Ceftriaxone and Linzess together, and have interactions are studied.

Ceftriaxone and Linzess drug interactions.

What are the common drug interactions of Ceftriaxone and Linzess, by gender? *:

female:

Fatigue (feeling of tiredness)
Headache (pain in head)
Multiple allergies (allergy to multiple agents)
Retching (strong involuntary effort to vomit)
Rib fracture
Skin irritation
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Smoke sensitivity
Upper respiratory tract infection
Urethral polyp

male:

Abdominal distension
Abdominal pain
Dehydration (dryness resulting from the removal of water)
Depression
Device dislocation
Diarrhoea
Diplopia (double vision)
Dizziness
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Ceftriaxone and Linzess, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Post procedural complication
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hypercoagulation (increased tendency for clotting of the blood)
Neuralgia (pain in one or more nerves)
Suicidal ideation
Colitis (inflammation of colon)
Drug hypersensitivity
Retching (strong involuntary effort to vomit)
Skin irritation

30-39:

n/a

40-49:

n/a

50-59:

Abscess limb (limb infection)
Cellulitis (infection under the skin)
Perirectal abscess
Subcutaneous abscess
Anal abscess
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Genital abscess (build up of pus in genital)
Hospitalisation
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Neoplasm (tumour)

60+:

Fall
Urinary tract infection
Haemorrhage (bleeding)
Headache (pain in head)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pain
Infusion site rash
Infusion site urticaria (rash of round, red welts on the skin at infusion site)
Kidney infection
Multiple allergies (allergy to multiple agents)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 21 people, 42.86%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 18 people, 36.73%
Immunodeficiency Common Variable: 12 people, 24.49%
Dehydration (dryness resulting from the removal of water): 6 people, 12.24%
High Blood Pressure: 5 people, 10.20%
Nausea (feeling of having an urge to vomit): 4 people, 8.16%
Hypotension (abnormally low blood pressure): 4 people, 8.16%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 8.16%
Fever: 4 people, 8.16%
Pain: 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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