Celecoxib and Savella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Celecoxib (celecoxib) and Savella (milnacipran hydrochloride). Common drug interactions include nausea among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Celecoxib and Savella. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Celecoxib?

Celecoxib has active ingredients of celecoxib. It is often used in arthritis. eHealthMe is studying from 38,217 Celecoxib users. Check the latest studies of Celecoxib.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

48 people who take Celecoxib and Savella together, and have interactions are studied.

Celecoxib and Savella drug interactions.

What are the common drug interactions of Celecoxib and Savella, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Weight decreased
Malaise (a feeling of general discomfort or uneasiness)
Arthralgia (joint pain)
Infusion related reaction
Infusion site pain
Skin disorder (skin disease)
Urinary tract infection
Cellulitis (infection under the skin)
Confusional state

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Multiple fractures
Radius fracture
Renal failure (kidney dysfunction)
Rib fracture
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Bipolar disorder (mood disorder)
Emotional distress
Hip fracture

What are the common drug interactions of Celecoxib and Savella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Migraine (headache)

40-49:

Anxiety
Chronic kidney disease
Renal failure (kidney dysfunction)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Asthenia (weakness)
Dental caries
Emotional distress
Headache (pain in head)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)

50-59:

Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Renal failure acute (rapid kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Chronic kidney disease
Gastric ulcer (stomach ulcer)
Suicidal ideation
Alopecia (absence of hair from areas of the body)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety

60+:

Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Infusion related reaction
Infusion site pain
Skin disorder (skin disease)
Stress
Urinary tract infection
Fatigue (feeling of tiredness)
Food allergy
Pain in extremity

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 11 people, 22.92%
High Blood Cholesterol: 8 people, 16.67%
Pain: 7 people, 14.58%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 7 people, 14.58%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 12.50%
High Blood Pressure: 6 people, 12.50%
Depression: 6 people, 12.50%
Nausea (feeling of having an urge to vomit): 5 people, 10.42%
Headache (pain in head): 5 people, 10.42%
Stress And Anxiety: 5 people, 10.42%

* Approximation only. Some reports may have incomplete information.

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