Celexa and Fiorinal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Celexa (citalopram hydrobromide) and Fiorinal (aspirin; butalbital; caffeine). Common drug interactions include compulsive hoarding among females and extrapyramidal disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Celexa and Fiorinal. It is created by eHealthMe based on reports of 71 people who take the same drugs from the FDA, and is updated regularly.

What is Celexa?

Celexa has active ingredients of citalopram hydrobromide. It is often used in depression. eHealthMe is studying from 56,390 Celexa users. Check the latest studies of Celexa.

What is Fiorinal?

Fiorinal has active ingredients of aspirin; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 2,714 Fiorinal users. Check the latest studies of Fiorinal.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

71 people who take Celexa and Fiorinal together, and have interactions are studied.

What are the common drug interactions of Celexa and Fiorinal, by gender? *:

female:

Compulsive hoarding (unwillingness to discard large quantities of objects that cover the living areas)
Compulsive sexual behaviour (unable to manage his/her sexual behaviour)
Compulsive shopping
Diarrhoea
Fall
Homeless
Hypertension (high blood pressure)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Maternal exposure during pregnancy (use of substance during pregnancy)
Neuropathy peripheral (surface nerve damage)

male:

Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Insomnia (sleeplessness)
Activities of daily living impaired
Agitation (state of anxiety or nervous excitement)
Balance disorder
Bruxism (habitual grinding of the teeth, typically during sleep)
Deformity (disfigurement)
Excessive eye blinking (excessive blinking is dry eyes)
Muscle spasms (muscle contraction)
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the common drug interactions of Celexa and Fiorinal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cerebral haemorrhage (bleeding within the brain)
Haematochezia (passage of stools containing blood)
Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain)
Hypertension (high blood pressure)
Insomnia (sleeplessness)
Platelet count decreased
Thrombocytopenia (decrease of platelets in blood)

20-29:

Influenza like illness
Injection site pain
Injection site reaction
Malaise (a feeling of general discomfort or uneasiness)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nuclear magnetic resonance imaging brain

30-39:

Fatigue (feeling of tiredness)
Pain
Insomnia (sleeplessness)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Conjunctivitis (pink eye)
Gastroenteritis (inflammation of stomach and intestine)
Influenza like illness
Loss of consciousness
Tooth abscess (pus formation in tooth)

40-49:

Somnolence (a state of near-sleep, a strong desire for sleep)
Dizziness
Fall
Fatigue (feeling of tiredness)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Mood swings (an extreme or rapid change in mood)
Abnormal behaviour
Aggression
Asthenia (weakness)
Body height decreased

50-59:

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Hypoxia (low oxygen in tissues)
Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
Hysterectomy
Ill-defined disorder
Injury
Lethargy (tiredness)
Limb discomfort (discomfort in leg)
Malaise (a feeling of general discomfort or uneasiness)
Asthma

60+:

Diarrhoea
Cellulitis (infection under the skin)
Hypoaesthesia (reduced sense of touch or sensation)
Intervertebral disc protrusion (spinal disc protrusion)
Pain in jaw
Renal failure (kidney dysfunction)
Urinary retention (the inability to completely or partially empty the bladder)
Vision blurred
Weight increased
Hypertension (high blood pressure)

What are the existing conditions these people have? *

Insomnia (sleeplessness): 7 people, 9.86%
Headache (pain in head): 7 people, 9.86%
Stress And Anxiety: 6 people, 8.45%
Pain: 6 people, 8.45%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 8.45%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 8.45%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 8.45%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 7.04%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 5.63%
High Blood Pressure: 4 people, 5.63%

* Approximation only. Some reports may have incomplete information.

Do you take Celexa and Fiorinal?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously