Cellcept and Alkeran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cellcept (mycophenolate mofetil) and Alkeran (melphalan). Common drug interactions include stomatitis among females and acute graft versus host disease in intestine among males.

The phase IV clinical study analyzes what interactions people have when they take Cellcept and Alkeran. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Cellcept?

Cellcept has active ingredients of mycophenolate mofetil. It is often used in systemic lupus erythematosus. eHealthMe is studying from 41,872 Cellcept users. Check the latest studies of Cellcept.

What is Alkeran?

Alkeran has active ingredients of melphalan. eHealthMe is studying from 5,429 Alkeran users. Check the latest studies of Alkeran.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

43 people who take Cellcept and Alkeran together, and have interactions are studied.

What are the common drug interactions of Cellcept and Alkeran, by gender? *:

female:

Stomatitis (inflammation of mucous membrane of mouth)
Alanine aminotransferase increased
Anuria (failure of the kidneys to produce urine)
Aspartate aminotransferase increased
Atelectasis (partial or complete collapse of the lung)
Bone pain
Brain stem haemorrhage (bleeding into structures of brain stem)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Cardiac failure
Cerebral haemorrhage (bleeding within the brain)

male:

Acute graft versus host disease in intestine (acute complication in intestine following an allogeneic tissue/blood transplant)
Venoocclusive liver disease (small veins in the liver are obstructed)
Rash
Diarrhoea
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematemesis (vomiting of blood)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Pulmonary oedema (fluid accumulation in the lungs)
Pneumonia
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)

What are the common drug interactions of Cellcept and Alkeran, by age (0-1 to 60+)? *:

0-1:

Pulmonary oedema (fluid accumulation in the lungs)
Venoocclusive liver disease (small veins in the liver are obstructed)
Ascites (accumulation of fluid in the abdominal cavity)
Bone marrow failure
Haematemesis (vomiting of blood)
Hepatomegaly (abnormal enlargement of the liver)
Melaena (the passage of black, tarry stools)
Pyrexia (fever)
Rash
Peptic ulcer haemorrhage (peptic ulcer bleeding)

2-9:

Stomatitis (inflammation of mucous membrane of mouth)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Venoocclusive disease (small veins in the liver are obstructed)
Aphasia (damage to the parts of the brain that control language)
Depressed level of consciousness
Monoparesis (one limb is very weak, but not completely paralyzed)
Muscular weakness (muscle weakness)
Myelitis transverse (a neurological condition consisting of an inflammatory process of the spinal cord)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Neuropathy peripheral (surface nerve damage)

10-19:

Febrile neutropenia (fever with reduced white blood cells)
Pyrexia (fever)
Anuria (failure of the kidneys to produce urine)
Bone density decreased
Bone pain
Cataract (clouding of the lens inside the eye)
Cystitis haemorrhagic (blood in the urine and painful voiding)
Cytomegalovirus test positive
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)

20-29:

Venoocclusive liver disease (small veins in the liver are obstructed)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Infection
Respiratory failure (inadequate gas exchange by the respiratory system)
Alanine aminotransferase increased
Altered state of consciousness (altered state of mind)
Aspartate aminotransferase increased
Blood bilirubin increased
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)

30-39:

Blood creatinine increased
Blood urea increased
Cardiac failure
Diarrhoea
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Interstitial lung disease
Renal impairment (severely reduced kidney function)
Systemic candida (whole body fungal infection)
Acute graft versus host disease in intestine (acute complication in intestine following an allogeneic tissue/blood transplant)
Sepsis (a severe blood infection that can lead to organ failure and death)

40-49:

Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Atelectasis (partial or complete collapse of the lung)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Cardiac failure
Decreased appetite
Diarrhoea
Erythema multiforme (a type of hypersensitivity reaction)

50-59:

Acute graft versus host disease in intestine (acute complication in intestine following an allogeneic tissue/blood transplant)
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Encephalitis herpes (inflammation of the brain due to herpes infection)
Blood pressure decreased
Cholinergic syndrome (symptoms of increased cholinergic stimulation)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Drug ineffective

60+:

Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Fungal infection
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumonia
Pruritus (severe itching of the skin)
Pulmonary haemorrhage (acute bleeding from the lung)
Pyrexia (fever)
Rash
Thrombocytopenia (decrease of platelets in blood)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)

What are the existing conditions these people have? *

Immunodeficiency Disorders: 19 people, 44.19%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 6 people, 13.95%
Bone Marrow Conditioning Regimen: 4 people, 9.30%
Sedation: 3 people, 6.98%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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