Centrum silver and Arthrotec drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Centrum silver (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) and Arthrotec (diclofenac sodium; misoprostol). Common drug interactions include back pain among females and chills among males.

The phase IV clinical study analyzes what interactions people have when they take Centrum silver and Arthrotec. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Centrum silver?

Centrum silver has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 19,997 Centrum silver users. Check the latest studies of Centrum silver.

What is Arthrotec?

Arthrotec has active ingredients of diclofenac sodium; misoprostol. It is often used in arthritis. eHealthMe is studying from 11,986 Arthrotec users. Check the latest studies of Arthrotec.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

52 people who take Centrum silver and Arthrotec together, and have interactions are studied.

Centrum silver and Arthrotec drug interactions.

What are the common drug interactions of Centrum Silver and Arthrotec, by gender? *:

female:

Back pain
Arthralgia (joint pain)
Chronic kidney disease
Constipation
Neck pain
Pain in extremity
Peripheral swelling
Renal injury (kidney injury)
Body height decreased
Drug ineffective

male:

Chills (felling of cold)
Pyrexia (fever)
Dysgeusia (disorder of the sense of taste)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Surgery
Headache (pain in head)
Drug ineffective
Influenza like illness
Escherichia infection (bacterial infection by escherichia coli)

What are the common drug interactions of Centrum Silver and Arthrotec, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anal pruritus (anal itching)
Back disorder
Cervical myelopathy (clinical syndrome characterized by clumsiness in hands; gait imbalance; caused by compression of the spinal cord)
Cor pulmonale acute (rapid enlargement of the right ventricle of the heart)
Depression
Eye swelling
Haemorrhoidal haemorrhage (bleeding from the haemorrhoids)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Ill-defined disorder
Intervertebral disc disorder (spinal disc disorder)

40-49:

n/a

50-59:

Chills (felling of cold)
Pyrexia (fever)
Oedema peripheral (superficial swelling)
Painful respiration
Intervertebral disc degeneration (spinal disc degeneration)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Surgery

60+:

Back pain
Arthralgia (joint pain)
Hypoaesthesia (reduced sense of touch or sensation)
Myalgia (muscle pain)
Arthropathy
Contusion (a type of hematoma of tissue in which capillaries)
Drug ineffective
Hip fracture
Photosensitivity reaction
Cataract (clouding of the lens inside the eye)

What are the existing conditions these people have? *

Pain: 15 people, 28.85%
High Blood Pressure: 15 people, 28.85%
Muscle Spasms (muscle contraction): 13 people, 25.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 12 people, 23.08%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 19.23%
Joint Pain: 8 people, 15.38%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 13.46%
Neuropathy Peripheral (surface nerve damage): 7 people, 13.46%
Lung Infection: 6 people, 11.54%
Gait Disturbance: 6 people, 11.54%

* Approximation only. Some reports may have incomplete information.

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