Centrum silver and Onglyza drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Centrum silver (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) and Onglyza (saxagliptin hydrochloride). Common drug interactions include pain in jaw among females and blood glucose increased among males.

The phase IV clinical study analyzes what interactions people have when they take Centrum silver and Onglyza. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Centrum silver?

Centrum silver has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 19,997 Centrum silver users. Check the latest studies of Centrum silver.

What is Onglyza?

Onglyza has active ingredients of saxagliptin hydrochloride. It is often used in diabetes. eHealthMe is studying from 8,638 Onglyza users. Check the latest studies of Onglyza.



On Jul, 14, 2026

47 people who take Centrum silver and Onglyza together, and have interactions are studied.

Centrum silver and Onglyza drug interactions.

What are the common drug interactions of Centrum Silver and Onglyza, by gender? *:

female:

  1. Pain in jaw
  2. Platelet count decreased
  3. Precancerous skin lesion
  4. Productive cough
  5. Pruritus (severe itching of the skin)
  6. Pulmonary congestion (congestion in the lungs)
  7. Rectal haemorrhage (bleeding from anus)
  8. Rehabilitation therapy
  9. Renal disorder (kidney disease)
  10. Dehydration (dryness resulting from the removal of water)

male:

  1. Blood glucose increased
  2. Anxiety
  3. Metamorphopsia (a type of distorted vision in which a grid of straight lines appears wavy and parts of the grid may appear blank)
  4. Mood swings (an extreme or rapid change in mood)
  5. Pancreatic pseudocyst (collection of tissue and fluids that forms on pancreas)
  6. Pancreatitis (inflammation of pancreas)
  7. Pancreatitis acute (sudden inflammation of pancreas)
  8. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  9. Pneumonia
  10. Renal cell carcinoma (a kidney cancer)

What are the common drug interactions of Centrum Silver and Onglyza, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Alopecia (absence of hair from areas of the body)
  2. Anxiety
  3. Diarrhoea
  4. Faecal incontinence (a lack of control over passing stool)
  5. Laryngitis (inflammation of the larynx)
  6. Malaise (a feeling of general discomfort or uneasiness)
  7. Mood swings (an extreme or rapid change in mood)
  8. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  9. Pulmonary congestion (congestion in the lungs)

60+:

  1. Dehydration (dryness resulting from the removal of water)
  2. Hypokalaemia (low potassium)
  3. Diarrhoea
  4. Electrolyte imbalance
  5. Nervousness
  6. Psychiatric symptom
  7. Somnolence (a state of near-sleep, a strong desire for sleep)
  8. Terminal insomnia (a sleep disorder in which there is an inability to fall asleep or to stay asleep as long as desired)
  9. Blood glucose increased
  10. Chest pain

What are the existing conditions these people have? *

  1. Lung Adenocarcinoma (a form of non-small cell lung cancer): 6 people, 12.77%
  2. Hyperkalemia (damage to or disease of the kidney): 5 people, 10.64%
  3. High Blood Pressure: 5 people, 10.64%
  4. High Blood Cholesterol: 5 people, 10.64%
  5. Kidney Stones: 4 people, 8.51%
  6. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 8.51%
  7. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 8.51%
  8. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

Do you take Centrum silver and Onglyza?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Centrum silver and Onglyza:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Centrum silver:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Onglyza:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Centrum silver and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Onglyza and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e and saxagliptin hydrochloride (the active ingredients of Centrum silver and Onglyza, respectively), and Centrum silver and Onglyza (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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