Centrum silver and Xiidra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Centrum silver (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) and Xiidra (lifitegrast). Common drug interactions include anaemia among females and eye pruritus among males.

The phase IV clinical study analyzes what interactions people have when they take Centrum silver and Xiidra. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Centrum silver?

Centrum silver has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 19,997 Centrum silver users. Check the latest studies of Centrum silver.

What is Xiidra?

Xiidra has active ingredients of lifitegrast. eHealthMe is studying from 15,244 Xiidra users. Check the latest studies of Xiidra.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

32 people who take Centrum silver and Xiidra together, and have interactions are studied.

Centrum silver and Xiidra drug interactions.

What are the common drug interactions of Centrum Silver and Xiidra, by gender? *:

female:

Anaemia (lack of blood)
Dysgeusia (disorder of the sense of taste)
Instillation site pain
Instillation site reaction
Vision blurred
Eye irritation
Eye pain
Visual impairment
Decreased appetite
Eye discharge

male:

Eye pruritus (eye itching)
Overdose
On and off phenomenon
Syncope (loss of consciousness with an inability to maintain postural tone)
Back pain
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Delusion (a false belief or opinion)
Dysgeusia (disorder of the sense of taste)
Hallucination (an experience involving the perception of something not present)
Headache (pain in head)

What are the common drug interactions of Centrum Silver and Xiidra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Dysgeusia (disorder of the sense of taste)
Burning sensation
Decreased appetite
Eye discharge
Eye irritation
Ocular hyperaemia (an abnormally large amount of blood in eye)
Screaming (a long loud piercing cry)

60+:

Eye pain
Instillation site pain
Overdose
Blood pressure increased
Drug ineffective
Instillation site discomfort
Instillation site irritation
Instillation site lacrimation
Agitation (state of anxiety or nervous excitement)
Anxiety

What are the existing conditions these people have? *

Dry Eyes (lack of adequate tears): 17 people, 53.12%
High Blood Pressure: 9 people, 28.12%
High Blood Cholesterol: 5 people, 15.62%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 15.62%
Pain: 4 people, 12.50%
Sleep Disorder: 3 people, 9.38%
Cardiac Disorder: 3 people, 9.38%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 9.38%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 9.38%
Drowsiness: 3 people, 9.38%

* Approximation only. Some reports may have incomplete information.

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