Centrum and Pulmozyme drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) and Pulmozyme (dornase alfa). Common drug interactions include lung disorder among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Centrum and Pulmozyme. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

What is Pulmozyme?

Pulmozyme has active ingredients of dornase alfa. It is often used in cystic fibrosis. eHealthMe is studying from 20,012 Pulmozyme users. Check the latest studies of Pulmozyme.

On Jul, 20, 2026

28 people who take Centrum and Pulmozyme together, and have interactions are studied.

Centrum and Pulmozyme drug interactions.

What are the common drug interactions of Centrum and Pulmozyme, by gender? *:

female:

Lung disorder (lung disease)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Body temperature increased
Colon cancer metastatic (cancer of colon spreads to other part of body)
Cough
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hospitalisation
Hypoaesthesia (reduced sense of touch or sensation)

male:

Abdominal pain upper
Dizziness
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Vomiting
Abnormal faeces (abnormal stool)
Hypersomnia (excessive daytime sleepiness (eds))
Infection
Influenza like illness
Lung transplant
Pulmonary function test decreased

What are the common drug interactions of Centrum and Pulmozyme, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Body temperature increased
Hospitalisation
Hypersomnia (excessive daytime sleepiness (eds))
Hypoaesthesia (reduced sense of touch or sensation)
Influenza like illness
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonia pseudomonal (pseudomonas pneumonia is an infection caused by the microbe known as pseudomonas aeruginosa)
Somnolence (a state of near-sleep, a strong desire for sleep)
White blood cell count decreased

20-29:

Lung disorder (lung disease)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Vomiting

30-39:

Forced expiratory volume decreased (decreased lung expired air volume)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Pneumonia
Colon cancer metastatic (cancer of colon spreads to other part of body)
Lung transplant

40-49:

Sepsis (a severe blood infection that can lead to organ failure and death)
Staphylococcal infection (an infection with staphylococcus bacteria)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Pulmonary function test decreased
Upper limb fracture

50-59:

n/a

60+:

Gastrointestinal disorder (functional problems of gastrointestinal tract)
Rash generalised (rash on most of body parts)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Abnormal faeces (abnormal stool)
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Infection
Pruritus generalised (generalized itching)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 5 people, 17.86%
Wheezing (a high-pitched whistling sound made while you breath): 4 people, 14.29%
Pain: 4 people, 14.29%
Cough: 4 people, 14.29%
Nausea And Vomiting: 3 people, 10.71%
Dyspnea (difficult or laboured breathing): 2 people, 7.14%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 7.14%
Chest Pain: 2 people, 7.14%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 7.14%
Costochondritis (chest wall pain): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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