Crestor and Mestinon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Crestor (rosuvastatin calcium) and Mestinon (pyridostigmine bromide). Common drug interactions include forearm fracture among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Crestor and Mestinon. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Crestor?

Crestor has active ingredients of rosuvastatin calcium. It is often used in high blood cholesterol. eHealthMe is studying from 149,761 Crestor users. Check the latest studies of Crestor.

What is Mestinon?

Mestinon has active ingredients of pyridostigmine bromide. It is often used in myasthenia gravis. eHealthMe is studying from 5,948 Mestinon users. Check the latest studies of Mestinon.

On Jul, 19, 2026

98 people who take Crestor and Mestinon together, and have interactions are studied.

What are the common drug interactions of Crestor and Mestinon, by gender? *:

female:

Forearm fracture (fracture in between wrist to elbow)
Gastric ulcer (stomach ulcer)
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Humerus fracture (injury to the upper arm bone)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Intervertebral disc protrusion (spinal disc protrusion)
Lower limb fracture
Oesophageal spasm (contraction of oesophagus)
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)

male:

Fatigue (feeling of tiredness)
Diplopia (double vision)
Lethargy (tiredness)
Low density lipoprotein decreased (cholesterol decreased)
Aortic aneurysm rupture (enlarged aortic artery rapture caused by a weakening of the artery wall)
Bacteraemia (presence of bacteria in the blood)
Beta 2 microglobulin urine increased
Blood pressure increased
Chest pain
Cholangitis (infection of the bile duct)

What are the common drug interactions of Crestor and Mestinon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arthropathy
Bone disorder
Bone pain
Cataract (clouding of the lens inside the eye)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Depression
Fracture delayed union (delayed cure of broken bone)
Humerus fracture (injury to the upper arm bone)
Osteoporosis (bones weak and more likely to break)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)

20-29:

n/a

30-39:

Depression
Fall
Femur fracture
Forearm fracture (fracture in between wrist to elbow)
Gastric ulcer (stomach ulcer)
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Lower limb fracture
Oesophageal spasm (contraction of oesophagus)

40-49:

Adverse event
Application site pain
Arthralgia (joint pain)
Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Fatigue (feeling of tiredness)
Gait disturbance
Hypersomnia (excessive daytime sleepiness (eds))
Mobility decreased (ability to move is reduced)

50-59:

Type 2 diabetes mellitus
Vocal cord polyp
Blood creatinine increased
Blood potassium increased
Blood urea increased
Breast cancer female
Chronic kidney disease
Fall
Gastric cancer (stomach cancer)
Headache (pain in head)

60+:

Toxic skin eruption (skin breakdown due to toxic substance)
Blood pressure increased
Disease progression
High density lipoprotein decreased
Hyperglycaemia (high blood sugar)
Lethargy (tiredness)
Low density lipoprotein decreased (cholesterol decreased)
Aortic aneurysm rupture (enlarged aortic artery rapture caused by a weakening of the artery wall)
Asthma
Bacteraemia (presence of bacteria in the blood)

What are the existing conditions these people have? *

High Blood Pressure: 13 people, 13.27%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 11.22%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 10.20%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 8.16%
Depression: 8 people, 8.16%
Dyslipidaemia (abnormal amount of lipids): 7 people, 7.14%
Parkinson's Disease: 6 people, 6.12%
Lambert-Eaton Syndrome (this means your immune system mistakenly targets healthy cells and tissues in the body): 6 people, 6.12%
Type 2 Diabetes: 5 people, 5.10%
Idiopathic Urticaria (allergic reactions, presence of hives with unknown cause): 5 people, 5.10%

* Approximation only. Some reports may have incomplete information.

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