Centrum and Ziac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) and Ziac (bisoprolol fumarate; hydrochlorothiazide). Common drug interactions include cough among females and upper gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Centrum and Ziac. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

What is Ziac?

Ziac has active ingredients of bisoprolol fumarate; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,451 Ziac users. Check the latest studies of Ziac.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

51 people who take Centrum and Ziac together, and have interactions are studied.

What are the common drug interactions of Centrum and Ziac, by gender? *:

female:

Cough
Cystitis interstitial (unknown cause characterized by bladder pain)
Deformity (disfigurement)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dry mouth
Dyspepsia (indigestion)
Dysphonia (speech disorder attributable to a disorder of phonation)
Pain
Renal failure (kidney dysfunction)
Anxiety

male:

Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Haematemesis (vomiting of blood)
Pulmonary mass
Restless legs syndrome (a powerful urge to move your legs)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Upper respiratory tract infection
Weight increased
Haematochezia (passage of stools containing blood)
Haemorrhage (bleeding)
Acute myocardial infarction (acute heart attack)

What are the common drug interactions of Centrum and Ziac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaphylactic reaction (serious allergic reaction)
Chronic myeloid leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood)
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Insomnia (sleeplessness)
Jaw disorder (jaw disease)
Pruritus (severe itching of the skin)
Rigors (an episode of shaking or exaggerated shivering)

50-59:

Piriformis syndrome (neuromuscular disorder that occurs when the sciatic nerve is compressed)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Thrombocytopenia (decrease of platelets in blood)
Upper respiratory tract infection
Weight increased
Pain
Chronic kidney disease
Renal failure (kidney dysfunction)
Acute myocardial infarction (acute heart attack)
Anaemia (lack of blood)

60+:

Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Anxiety
Asthenia (weakness)
Cataract (clouding of the lens inside the eye)
Depression
Malaise (a feeling of general discomfort or uneasiness)
Osteonecrosis (death of bone)
Spinal column stenosis (narrowing of spinal column)
Angiopathy (generic term for a disease of the blood vessels)
Arthritis (form of joint disorder that involves inflammation of one or more joints)

What are the existing conditions these people have? *

High Blood Cholesterol: 13 people, 25.49%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 19.61%
Diabetes: 8 people, 15.69%
Blood Pressure Abnormal: 7 people, 13.73%
Thyroid Diseases: 6 people, 11.76%
Fluid Retention (an abnormal accumulation of fluid in the blood): 6 people, 11.76%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 5 people, 9.80%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 9.80%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 7.84%
Neuropathy Peripheral (surface nerve damage): 4 people, 7.84%

* Approximation only. Some reports may have incomplete information.

Do you take Centrum and Ziac?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously