Cephalexin and Xiidra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cephalexin (cephalexin) and Xiidra (lifitegrast). Common drug interactions include asthenia among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Cephalexin and Xiidra. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Cephalexin?

Cephalexin has active ingredients of cephalexin. It is often used in infection. eHealthMe is studying from 30,580 Cephalexin users. Check the latest studies of Cephalexin.

What is Xiidra?

Xiidra has active ingredients of lifitegrast. eHealthMe is studying from 15,244 Xiidra users. Check the latest studies of Xiidra.



On Jul, 19, 2026

37 people who take Cephalexin and Xiidra together, and have interactions are studied.

Cephalexin and Xiidra drug interactions.

What are the common drug interactions of Cephalexin and Xiidra, by gender? *:

female:

  1. Asthenia (weakness)
  2. Dry eye (lack of adequate tears)
  3. Pain
  4. Dizziness
  5. Influenza
  6. Joint injury
  7. Pruritus (severe itching of the skin)
  8. Rash
  9. Back disorder
  10. Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)

male:

  1. Death
  2. Drug ineffective
  3. Eye pain
  4. Instillation site reaction
  5. Vision blurred
  6. Visual impairment

What are the common drug interactions of Cephalexin and Xiidra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Arthralgia (joint pain)
  2. Asthenia (weakness)
  3. Back disorder
  4. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  5. Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
  6. Dizziness
  7. Dry eye (lack of adequate tears)
  8. Dry mouth
  9. Fall
  10. Fatigue (feeling of tiredness)

60+:

  1. Fall
  2. Culture urine positive
  3. Disease progression
  4. Dry eye (lack of adequate tears)
  5. Laryngitis (inflammation of the larynx)
  6. Meibomian gland dysfunction (dry eyes)
  7. Mobility decreased (ability to move is reduced)
  8. Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
  9. Myopia (difficult to see objects that are far away)
  10. Pain in extremity

What are the existing conditions these people have? *

  1. Hereditary Neuropathic Amyloidosis (hereditary- diseases resulting from abnormal deposition of certain proteins (amyloid) in various bodily areas by problems with signals from the nerves): 7 people, 18.92%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 16.22%
  3. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 16.22%
  4. Lichen Myxoedematosus (deposition of acid mucopolysaccharides in the skin): 4 people, 10.81%
  5. Dry Eyes (lack of adequate tears): 3 people, 8.11%
  6. Psoriasis (immune-mediated disease that affects the skin): 2 people, 5.41%
  7. Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 2 people, 5.41%
  8. Multiple Myeloma (cancer of the plasma cells): 2 people, 5.41%
  9. Hiv Infection: 2 people, 5.41%
  10. Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Cephalexin and Xiidra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cephalexin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Xiidra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cephalexin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Xiidra and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on cephalexin and lifitegrast (the active ingredients of Cephalexin and Xiidra, respectively), and Cephalexin and Xiidra (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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