Cesamet and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cesamet (nabilone) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include drug ineffective among females and heart rate increased among males.

The phase IV clinical study analyzes what interactions people have when they take Cesamet and Benadryl. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Cesamet?

Cesamet has active ingredients of nabilone. It is often used in fibromyalgia. eHealthMe is studying from 548 Cesamet users. Check the latest studies of Cesamet.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,956 Benadryl users. Check the latest studies of Benadryl.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Aug, 31, 2026

12 people who take Cesamet and Benadryl together, and have interactions are studied.

Cesamet and Benadryl drug interactions.

What are the common drug interactions of Cesamet and Benadryl, by gender? *:

female:

  1. Drug ineffective
  2. Pain
  3. Stress
  4. Suicidal ideation

male:

  1. Heart rate increased
  2. Muscle spasms (muscle contraction)
  3. Blood pressure systolic increased

What are the common drug interactions of Cesamet and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Heart rate increased
  2. Muscle spasms (muscle contraction)
  3. Blood pressure systolic increased

30-39:

  1. Drug ineffective
  2. Pain
  3. Stress
  4. Suicidal ideation

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 41.67%
  2. Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 33.33%
  3. Constipation: 4 people, 33.33%
  4. Drowsiness: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Cesamet and Benadryl?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Cesamet and Benadryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cesamet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Benadryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cesamet and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Benadryl and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on nabilone and diphenhydramine hydrochloride (the active ingredients of Cesamet and Benadryl, respectively), and Cesamet and Benadryl (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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