Cevimeline and Promethazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cevimeline (cevimeline hydrochloride) and Promethazine (promethazine hydrochloride). Common drug interactions include arthralgia among females and dermatitis atopic among males.

The phase IV clinical study analyzes what interactions people have when they take Cevimeline and Promethazine. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Cevimeline?

Cevimeline has active ingredients of cevimeline hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 1,480 Cevimeline users. Check the latest studies of Cevimeline.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

On Jul, 11, 2026

37 people who take Cevimeline and Promethazine together, and have interactions are studied.

Cevimeline and Promethazine drug interactions.

What are the common drug interactions of Cevimeline and Promethazine, by gender? *:

female:

Arthralgia (joint pain)
Confusional state
Drug ineffective
Fall
Malaise (a feeling of general discomfort or uneasiness)
Weight decreased
Fluid overload (too much fluid in the blood)
Hypoxia (low oxygen in tissues)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Overdose

male:

Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Fatigue (feeling of tiredness)
Sleep disorder
Drug ineffective
Injection site reaction
Rash

What are the common drug interactions of Cevimeline and Promethazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Skin burning sensation
Skin exfoliation (removal of the oldest dead skin cells)
Vulval disorder

40-49:

Fall
Chills (felling of cold)
Fatigue (feeling of tiredness)
Feeling cold
Blood pressure increased
Breast cancer
Diarrhoea
Dizziness
Drug ineffective
Fibromyalgia (a long-term condition which causes pain all over the body)

50-59:

Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Drug ineffective
Fatigue (feeling of tiredness)
Sleep disorder
Injection site reaction
Fluid overload (too much fluid in the blood)
Hypoxia (low oxygen in tissues)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Overdose
Right ventricular failure (right half of the heart fails to work)

60+:

Wound
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Scab (a hard coating on the skin formed during the wound healing)
Therapeutic response unexpected
Weight decreased
Asthenia (weakness)
Burning sensation
Decreased appetite
Diarrhoea
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 32.43%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 32.43%
Insomnia (sleeplessness): 7 people, 18.92%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 5 people, 13.51%
Migraine (headache): 4 people, 10.81%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 10.81%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 10.81%
High Blood Pressure: 3 people, 8.11%
Dry Mouth: 3 people, 8.11%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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