Chestnut and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chestnut (horse chestnut) and Methotrexate (methotrexate sodium). Common drug interactions include rosacea among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Chestnut and Methotrexate. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Chestnut?

Chestnut has active ingredients of horse chestnut. eHealthMe is studying from 538 Chestnut users. Check the latest studies of Chestnut.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,314 Methotrexate users. Check the latest studies of Methotrexate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

19 people who take Chestnut and Methotrexate together, and have interactions are studied.

Chestnut and Methotrexate drug interactions.

What are the common drug interactions of Chestnut and Methotrexate, by gender? *:

female:

Rosacea (a skin condition that causes facial redness)
Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
Decreased appetite
Fall
Urinary tract infection
Adenoma benign (non-cancerous tumour -secreting)
Arthralgia (joint pain)
Bone erosion
Drug ineffective
Dyspnoea (difficult or laboured respiration)

male:

Arthralgia (joint pain)
Back pain
Nervousness
Pain
Pain in extremity
Pain of skin
Peripheral swelling
Skin discolouration (change of skin colour)
Burning sensation
Spinal disorder (disease of spine a back bone)

What are the common drug interactions of Chestnut and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Viral load increased
Appendicitis (inflammation of the appendix)

20-29:

n/a

30-39:

n/a

40-49:

Arthralgia (joint pain)
Bone erosion
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Fall
Gait disturbance
Headache (pain in head)
Influenza
Limb asymmetry (consistent task discrepancy between the two lower limbs)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

50-59:

Rosacea (a skin condition that causes facial redness)
Decreased appetite
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Abdominal discomfort
Anxiety
Depression
Diarrhoea
Fall
Finger deformity (a deformed position of the finger)
Grip strength decreased

60+:

Arthralgia (joint pain)
Back pain
Nervousness
Pain
Pain in extremity
Pain of skin
Peripheral swelling
Skin discolouration (change of skin colour)
Burning sensation
Spinal disorder (disease of spine a back bone)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 36.84%
Varicose Vein (veins that have become enlarged and tortuous): 4 people, 21.05%
Nail Disorder (disease of nail): 4 people, 21.05%
Hair Disorder: 4 people, 21.05%
Inflammation: 4 people, 21.05%
Allergies: 4 people, 21.05%
Skin Disorder (skin disease): 4 people, 21.05%
Neuropathy Peripheral (surface nerve damage): 3 people, 15.79%
Heart Disease: 3 people, 15.79%
Bone Disorder: 3 people, 15.79%

* Approximation only. Some reports may have incomplete information.

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