Chloramphenicol and Acyclovir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chloramphenicol (chloramphenicol) and Acyclovir (acyclovir). Common drug interactions include pancytopenia among females and lower respiratory tract infection among males.

The phase IV clinical study analyzes what interactions people have when they take Chloramphenicol and Acyclovir. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Chloramphenicol?

Chloramphenicol has active ingredients of chloramphenicol. eHealthMe is studying from 2,581 Chloramphenicol users. Check the latest studies of Chloramphenicol.

What is Acyclovir?

Acyclovir has active ingredients of acyclovir. It is often used in herpes simplex. eHealthMe is studying from 54,961 Acyclovir users. Check the latest studies of Acyclovir.

On Jul, 12, 2026

41 people who take Chloramphenicol and Acyclovir together, and have interactions are studied.

Chloramphenicol and Acyclovir drug interactions.

What are the common drug interactions of Chloramphenicol and Acyclovir, by gender? *:

female:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Photophobia (extreme sensitivity to light)
Pneumonia
Pruritus (severe itching of the skin)
Pyrexia (fever)
Rash
Red man syndrome (a reaction to the drug vancomycin)
Sepsis (a severe blood infection that can lead to organ failure and death)
Stomatitis (inflammation of mucous membrane of mouth)

male:

Lower respiratory tract infection
Febrile neutropenia (fever with reduced white blood cells)
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Cerebral thrombosis (blood clot in brain)
Cushingoid (obesity and weakening of the muscles)
Drug ineffective
Encephalitis (inflammation of the brain)
Epstein-barr virus associated lymphoproliferative disorder (lymphocytes are produced in excessive quantities associated with epstein-barr virus)
Fatigue (feeling of tiredness)
General physical health deterioration (weak health status)

What are the common drug interactions of Chloramphenicol and Acyclovir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Febrile neutropenia (fever with reduced white blood cells)
Heart rate increased
Lymphocyte count decreased
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Pyrexia (fever)
Rhinorrhoea (watery mucus discharge from the nose)
White blood cell count decreased
Anaemia (lack of blood)
Clostridial infection (infectious conditions by clostridium bacteria)
Contusion (a type of hematoma of tissue in which capillaries)

10-19:

Cushingoid (obesity and weakening of the muscles)
Drug ineffective
Gynaecomastia (enlargement of the gland tissue of the male breast)
Lipohypertrophy (a lump under the skin caused by accumulation of extra fat at the site of many subcutaneous injections of insulin)
Skin hyperpigmentation (disorders affect the colour of your skin)
Skin striae (irregular areas of skin that look like bands, stripes, or lines)
Weight increased
Rash

20-29:

Gingivitis (inflammation of gums)
Headache (pain in head)
Oropharyngeal pain
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Photophobia (extreme sensitivity to light)
Red man syndrome (a reaction to the drug vancomycin)
Visual impairment
Weight increased

30-39:

Encephalitis (inflammation of the brain)
Hyperkalaemia (damage to or disease of the kidney)
Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)
Meningitis cryptococcal (bacterial inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Renal failure acute (rapid kidney dysfunction)

40-49:

Epstein-barr virus associated lymphoproliferative disorder (lymphocytes are produced in excessive quantities associated with epstein-barr virus)
Febrile neutropenia (fever with reduced white blood cells)
Insomnia (sleeplessness)
Diarrhoea
Disease progression
Staphylococcal skin infection (skin infection by an infection with staphylococcus bacteria)
Vomiting

50-59:

Headache (pain in head)
Bradycardia (abnormally slow heart action)
Non-alcoholic steatohepatitis (liver inflammation caused by a build up of fat in the liver)
Hordeolum (small collection of pus (abscess) on the eyelid)
Abdominal pain
Abdominal pain upper
Atrioventricular block first degree (heart block first degree)
Blood creatinine increased
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)

60+:

Lower respiratory tract infection
Diarrhoea
Cerebral thrombosis (blood clot in brain)
Fatigue (feeling of tiredness)
General physical health deterioration (weak health status)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Syncope (loss of consciousness with an inability to maintain postural tone)
Asthenia (weakness)
Cellulitis orbital (acute spread of infection into the eye socket)
Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 8 people, 19.51%
Constipation: 5 people, 12.20%
Pain: 4 people, 9.76%
Infection: 3 people, 7.32%
Herpes Zoster: 3 people, 7.32%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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