Chlorothiazide and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chlorothiazide (chlorothiazide) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include cardiac arrest among females and blood bilirubin increased among males.

The phase IV clinical study analyzes what interactions people have when they take Chlorothiazide and Hydroxyzine. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Chlorothiazide?

Chlorothiazide has active ingredients of chlorothiazide. eHealthMe is studying from 1,220 Chlorothiazide users. Check the latest studies of Chlorothiazide.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

On Jul, 13, 2026

33 people who take Chlorothiazide and Hydroxyzine together, and have interactions are studied.

Chlorothiazide and Hydroxyzine drug interactions.

What are the common drug interactions of Chlorothiazide and Hydroxyzine, by gender? *:

female:

Cardiac arrest
Drug ineffective
Nausea (feeling of having an urge to vomit)
Chest pain
Chloroma (green-coloured tumour)
Cough
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Depressed level of consciousness
Dyspnoea (difficult or laboured respiration)
Exophthalmos (bulging or protruding eyeball)

male:

Blood bilirubin increased
Engraftment syndrome (inflammatory condition during neutrophil recovery after hematopoietic stem cell transplantation)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Cardiac arrest
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Dyspnoea (difficult or laboured respiration)
Irritability
Rectal haemorrhage (bleeding from anus)
Renal failure acute (rapid kidney dysfunction)
Acute graft versus host disease in liver (acute complication in liver following an allogeneic tissue/blood transplant)

What are the common drug interactions of Chlorothiazide and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

Drug ineffective
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Hepatotoxicity (chemical-driven liver damage)
Liver injury

2-9:

Irritability
Depressed level of consciousness
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Dyspnoea (difficult or laboured respiration)

10-19:

Blood bilirubin increased
Cardiac arrest
Nausea (feeling of having an urge to vomit)
Chest pain
Chloroma (green-coloured tumour)
Cough
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Depressed level of consciousness
Drug ineffective
Dyspnoea (difficult or laboured respiration)

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)

50-59:

n/a

60+:

Blood potassium decreased
Chronic kidney disease
Haemoglobin decreased
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Rectal haemorrhage (bleeding from anus)

What are the existing conditions these people have? *

Pain: 10 people, 30.30%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 9 people, 27.27%
Flatulence (flatus expelled through the anus): 8 people, 24.24%
Adenovirus Infection: 6 people, 18.18%
Itching: 6 people, 18.18%
The Flu (the flu is caused by an influenza virus): 6 people, 18.18%
Respiratory Distress (difficulty in breathing): 6 people, 18.18%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 6 people, 18.18%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 5 people, 15.15%
High Blood Pressure: 5 people, 15.15%

* Approximation only. Some reports may have incomplete information.

Do you take Chlorothiazide and Hydroxyzine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously