Chlorothiazide and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chlorothiazide (chlorothiazide) and Melatonin (melatonin). Common drug interactions include hypoglycaemia among females and serotonin syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Chlorothiazide and Melatonin. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Chlorothiazide?

Chlorothiazide has active ingredients of chlorothiazide. eHealthMe is studying from 1,220 Chlorothiazide users. Check the latest studies of Chlorothiazide.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,213 Melatonin users. Check the latest studies of Melatonin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

73 people who take Chlorothiazide and Melatonin together, and have interactions are studied.

Chlorothiazide and Melatonin drug interactions.

What are the common drug interactions of Chlorothiazide and Melatonin, by gender? *:

female:

Hypoglycaemia (deficiency of glucose in the bloodstream)
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Nausea (feeling of having an urge to vomit)
Nephropathy toxic (damage to kidney due to toxins)
Neutropenia (an abnormally low number of neutrophils)
Organising pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumonia fungal
Pulmonary hypertension (increase in blood pressure in the lung artery)

male:

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Cardiac arrest
Brain injury
Ileus (a painful obstruction of the ileum or other part of the intestine)
Drug clearance decreased
Flushing (the warm, red condition of human skin)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hypoxia (low oxygen in tissues)
Liver injury
Loss of consciousness

What are the common drug interactions of Chlorothiazide and Melatonin, by age (0-1 to 60+)? *:

0-1:

Hypotension (abnormally low blood pressure)
Hypotonia (low muscle tone)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Myoclonic epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs)
Pneumonia
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Respiratory distress (difficulty in breathing)
Respiratory failure (inadequate gas exchange by the respiratory system)
Serratia infection (bacterial infection)

2-9:

Hypotension (abnormally low blood pressure)
Renal impairment (severely reduced kidney function)
Abdominal distension
Circulatory collapse
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Device dislocation
Dyspnoea (difficult or laboured respiration)
Generalised oedema (swelling all over the body)
Irritability
Oxygen saturation decreased

10-19:

Respiratory failure (inadequate gas exchange by the respiratory system)
Abdominal pain
Bacterial infection
Blood bilirubin increased
Cardiac arrest
Nausea (feeling of having an urge to vomit)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Lipoma (a growth of fatty tissue that slowly develops just under your skin)
Contusion (a type of hematoma of tissue in which capillaries)
Decreased appetite

20-29:

Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Loss of consciousness
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Tracheostomy infection (infection of trachea surgical opening)
Pyrexia (fever)
Respiratory disorder (respiratory disease)
Pneumonia

30-39:

n/a

40-49:

Chest pain
Fluid overload (too much fluid in the blood)
Polyuria (production of too much dilute urine)
Pulmonary hypertension (increase in blood pressure in the lung artery)

50-59:

Cardiac failure congestive

60+:

Acute respiratory failure
Encephalopathy (functioning of the brain is affected by some agent or condition)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Opportunistic infection (a microorganism that normally does not cause disease but becomes pathogenic when the body's immune system is impaired and unable to fight)
Anaemia (lack of blood)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Cholecystitis (infection of gallbladder)
Colitis (inflammation of colon)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Hypoglycaemia (deficiency of glucose in the bloodstream)

What are the existing conditions these people have? *

Pain: 15 people, 20.55%
Infection: 12 people, 16.44%
Agitation (state of anxiety or nervous excitement): 10 people, 13.70%
Lower Respiratory Tract Infection: 9 people, 12.33%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 8 people, 10.96%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 8 people, 10.96%
Immunodeficiency Common Variable: 7 people, 9.59%
Hypotension (abnormally low blood pressure): 7 people, 9.59%
Constipation: 7 people, 9.59%
Adenovirus Infection: 7 people, 9.59%

* Approximation only. Some reports may have incomplete information.

Do you take Chlorothiazide and Melatonin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously