Chlorthalidone and Prograf drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chlorthalidone (chlorthalidone) and Prograf (tacrolimus). Common drug interactions include malaise among females and myalgia among males.

The phase IV clinical study analyzes what interactions people have when they take Chlorthalidone and Prograf. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Chlorthalidone?

Chlorthalidone has active ingredients of chlorthalidone. It is often used in high blood pressure. eHealthMe is studying from 12,482 Chlorthalidone users. Check the latest studies of Chlorthalidone.

What is Prograf?

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.

On Jul, 16, 2026

42 people who take Chlorthalidone and Prograf together, and have interactions are studied.

Chlorthalidone and Prograf drug interactions.

What are the common drug interactions of Chlorthalidone and Prograf, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Pericardial effusion (fluid around the heart)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Spinal cord injury
Cardiac disorder
Renal failure (kidney dysfunction)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Cardiac failure congestive
Heart transplant rejection
Death

male:

Myalgia (muscle pain)
Oedema peripheral (superficial swelling)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic dilatation
Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Balance disorder
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Benign prostatic hyperplasia (benign enlargement of the prostate)

What are the common drug interactions of Chlorthalidone and Prograf, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood creatinine increased
Hyperkalaemia (damage to or disease of the kidney)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)

40-49:

Oedema peripheral (superficial swelling)
Pain
Abdominal distension
Cardiac failure
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Impaired work ability
Malaise (a feeling of general discomfort or uneasiness)
Pericardial effusion (fluid around the heart)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

50-59:

Fatigue (feeling of tiredness)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Infusion related reaction
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Weight increased
Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)

60+:

Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Urinary tract infection
Blood pressure fluctuation
Bradycardia (abnormally slow heart action)
C-reactive protein increased
Carotid arteriosclerosis (plaque deposition in artery)
Chronic kidney disease
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Dizziness
Fear

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 7 people, 16.67%
Immunodeficiency Disorders: 5 people, 11.90%
Haemorrhage Intracranial (bleeding within the skull): 5 people, 11.90%
Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 11.90%
Weakness: 4 people, 9.52%
Headache (pain in head): 4 people, 9.52%
Back Pain: 4 people, 9.52%
Disease Progression: 4 people, 9.52%
Dry Skin: 4 people, 9.52%
Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 4 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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