Cialis and Diflucan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cialis (tadalafil) and Diflucan (fluconazole). Common drug interactions include hot flush among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Cialis and Diflucan. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Cialis?

Cialis has active ingredients of tadalafil. It is often used in erection problems. eHealthMe is studying from 28,532 Cialis users. Check the latest studies of Cialis.

What is Diflucan?

Diflucan has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 28,471 Diflucan users. Check the latest studies of Diflucan.

On Aug, 01, 2026

63 people who take Cialis and Diflucan together, and have interactions are studied.

What are the common drug interactions of Cialis and Diflucan, by gender? *:

female:

Hot flush (sudden feelings of heat)
Immune system disorder
Joint swelling
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Pain
Thyroid neoplasm (tumour of thyroid)
Vomiting
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

male:

Pain
Dyspnoea (difficult or laboured respiration)
Pneumonia
Vomiting
Cholecystitis (infection of gallbladder)
Cough
Diarrhoea
Osteonecrosis (death of bone)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)

What are the common drug interactions of Cialis and Diflucan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Diarrhoea
Dizziness
Flushing (the warm, red condition of human skin)
Gastric disorder (disease of stomach)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hot flush (sudden feelings of heat)
Nausea (feeling of having an urge to vomit)
Vomiting

40-49:

Ileitis (inflammation of the ileum)
Cholecystitis (infection of gallbladder)
Osteonecrosis (death of bone)
Nausea (feeling of having an urge to vomit)
Pain
Anaemia (lack of blood)
Ankle fracture
Arthralgia (joint pain)
Chronic kidney disease
Diarrhoea

50-59:

Oral intake reduced
Osteopenia (a condition where bone mineral density is lower than normal)
Palpitations (feelings or sensations that your heart is pounding or racing)
Perforated ulcer
Pericardial effusion (fluid around the heart)
Pleural effusion (water on the lungs)
Pulmonary arterial pressure increased
Pulmonary oedema (fluid accumulation in the lungs)
Renal disorder (kidney disease)
Renal failure (kidney dysfunction)

60+:

Disease progression
Dyspnoea (difficult or laboured respiration)
Chills (felling of cold)
Chronic kidney disease
Depression
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain in extremity
Renal failure (kidney dysfunction)
Acute hepatic failure
Aphthous stomatitis (mouth ulcer)

What are the existing conditions these people have? *

Hiv Infection: 15 people, 23.81%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 11 people, 17.46%
Raynaud's Phenomenon (discoloration of the fingers, toes, and occasionally other areas): 11 people, 17.46%
Interstitial Lung Disease: 11 people, 17.46%

* Approximation only. Some reports may have incomplete information.

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