Cimetidine and Keflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cimetidine (cimetidine) and Keflex (cephalexin). Common drug interactions include dysphagia among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Cimetidine and Keflex. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Cimetidine?

Cimetidine has active ingredients of cimetidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 10,531 Cimetidine users. Check the latest studies of Cimetidine.

What is Keflex?

Keflex has active ingredients of cephalexin. It is often used in infection. eHealthMe is studying from 15,844 Keflex users. Check the latest studies of Keflex.



On Jul, 27, 2026

83 people who take Cimetidine and Keflex together, and have interactions are studied.

Cimetidine and Keflex drug interactions.

What are the common drug interactions of Cimetidine and Keflex, by gender? *:

female:

  1. Dysphagia (a condition in which swallowing is difficult or painful)
  2. Pleural effusion (water on the lungs)
  3. Anxiety
  4. Bone disorder
  5. Impaired healing
  6. Inflammation
  7. Tooth disorder (tooth disease)
  8. Anaemia (lack of blood)
  9. Pain in jaw
  10. Osteonecrosis of jaw (death of bone of jaw)

male:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Extravasation (leakage of a fluid)
  4. Inflammation
  5. Mucosal inflammation (infection of mucous membrane)
  6. Rash erythematous (redness of the skin)
  7. Rash macular (small, flat red spots)
  8. Rash papular (redness with papule)
  9. Renal injury (kidney injury)

What are the common drug interactions of Cimetidine and Keflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)

40-49:

  1. Dysphagia (a condition in which swallowing is difficult or painful)
  2. Erythema (redness of the skin)
  3. Pleural effusion (water on the lungs)
  4. Bone disorder
  5. Impaired healing
  6. Inflammation
  7. Tooth disorder (tooth disease)
  8. Tooth extraction
  9. Anaemia (lack of blood)
  10. Pain in jaw

50-59:

  1. Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
  2. Capillary leak syndrome (capillary leaks plasma)
  3. Cardiomegaly (increased size of heart than normal)
  4. Depressed mood
  5. Diarrhoea
  6. Dysphagia (a condition in which swallowing is difficult or painful)
  7. Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat)
  8. Exostosis (formation of new bone on the surface of a bone)
  9. Fall
  10. Family stress

60+:

  1. Chronic kidney disease
  2. Anxiety
  3. Nausea (feeling of having an urge to vomit)
  4. Dysphagia (a condition in which swallowing is difficult or painful)
  5. Erythema (redness of the skin)
  6. Mitral valve incompetence (inefficient heart valve)
  7. Nephrogenic anaemia (anaemia due to kidney disease)
  8. Oedema peripheral (superficial swelling)
  9. Pain in extremity
  10. Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)

What are the existing conditions these people have? *

  1. Pain: 40 people, 48.19%
  2. Breast Cancer: 32 people, 38.55%
  3. Depression: 30 people, 36.14%
  4. Metastases To Bone (cancer spreads to bone): 29 people, 34.94%
  5. High Blood Pressure: 20 people, 24.10%
  6. Metastasis (spreadable cancer to other organ from origin): 20 people, 24.10%
  7. Oedema (fluid collection in tissue): 16 people, 19.28%
  8. Inflammation: 15 people, 18.07%
  9. Breast Cancer Metastatic: 9 people, 10.84%
  10. Indigestion: 9 people, 10.84%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Cimetidine and Keflex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cimetidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Keflex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cimetidine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Keflex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on cimetidine and cephalexin (the active ingredients of Cimetidine and Keflex, respectively), and Cimetidine and Keflex (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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