Cipro and Donepezil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cipro (ciprofloxacin hydrochloride) and Donepezil (donepezil hydrochloride). Common drug interactions include central nervous system lesion among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Cipro and Donepezil. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Cipro?

Cipro has active ingredients of ciprofloxacin hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 35,126 Cipro users. Check the latest studies of Cipro.

What is Donepezil?

Donepezil has active ingredients of donepezil hydrochloride. It is often used in dementia. eHealthMe is studying from 24,564 Donepezil users. Check the latest studies of Donepezil.

On Jul, 12, 2026

73 people who take Cipro and Donepezil together, and have interactions are studied.

What are the common drug interactions of Cipro and Donepezil, by gender? *:

female:

Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Death
Dyspnoea (difficult or laboured respiration)
Hallucination (an experience involving the perception of something not present)
Long qt syndrome (disorder of the heart's electrical system)
Pain in extremity
Pneumonia
Somnolence (a state of near-sleep, a strong desire for sleep)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)

male:

Asthenia (weakness)
Nausea (feeling of having an urge to vomit)
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Anion gap decreased
Balance disorder
Blood albumin decreased
Blood alkaline phosphatase decreased
Blood calcium decreased
Blood creatine decreased

What are the common drug interactions of Cipro and Donepezil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Anion gap decreased
Asthenia (weakness)
Balance disorder
Blood albumin decreased
Blood alkaline phosphatase decreased
Blood calcium decreased
Blood creatine decreased
Blood glucose increased

50-59:

Fatigue (feeling of tiredness)
Fear
Hot flush (sudden feelings of heat)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Quality of life decreased
Renal failure (kidney dysfunction)

60+:

Diarrhoea
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Dyspnoea (difficult or laboured respiration)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hospitalisation
Long qt syndrome (disorder of the heart's electrical system)
Pneumonia
Prostatitis (inflammation of the prostate gland)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 9.59%
Stress And Anxiety: 6 people, 8.22%
High Blood Cholesterol: 6 people, 8.22%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 8.22%
Constipation: 6 people, 8.22%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 5 people, 6.85%
Parkinson's Disease: 5 people, 6.85%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 4 people, 5.48%
Agitation (state of anxiety or nervous excitement): 4 people, 5.48%

* Approximation only. Some reports may have incomplete information.

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