Cipro and Promethazine hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cipro (ciprofloxacin hydrochloride) and Promethazine hydrochloride (promethazine hydrochloride). Common drug interactions include anxiety among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Cipro and Promethazine hydrochloride. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Cipro?

Cipro has active ingredients of ciprofloxacin hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 35,126 Cipro users. Check the latest studies of Cipro.

What is Promethazine hydrochloride?

Promethazine hydrochloride has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 2,954 Promethazine hydrochloride users. Check the latest studies of Promethazine hydrochloride.

On Aug, 02, 2026

59 people who take Cipro and Promethazine hydrochloride together, and have interactions are studied.

Cipro and Promethazine hydrochloride drug interactions.

What are the common drug interactions of Cipro and Promethazine Hydrochloride, by gender? *:

female:

Anxiety
Pain in extremity
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Colitis (inflammation of colon)
Colitis ulcerative (inflammation of colon with ulcer)
Female genital tract fistula (passage in genital tract of female)
Frequent bowel movements
Haematochezia (passage of stools containing blood)
Infusion related reaction
Oral candidiasis (fungal infection of mouth)

male:

Abdominal distension
Pain
Chest discomfort
Chest pain
Constipation
Dehydration (dryness resulting from the removal of water)
Depression
Device dislocation
Diarrhoea
Diplopia (double vision)

What are the common drug interactions of Cipro and Promethazine Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Emotional distress
General physical health deterioration (weak health status)
Injury
Pain
Headache (pain in head)
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Chest pain
Hypocalcaemia (levels of calcium in blood serum are abnormally low)

30-39:

Sepsis (a severe blood infection that can lead to organ failure and death)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

40-49:

Hypophagia (reduced food intake)
Pain
Weight decreased
Abdominal distension
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic disorder
Aortic valve incompetence

50-59:

Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Confusional state
Cough
Crying
Decreased interest
Delusion (a false belief or opinion)
Device related infection
Diplopia (double vision)

60+:

Pain
Malaise (a feeling of general discomfort or uneasiness)
Colitis (inflammation of colon)
Colitis ulcerative (inflammation of colon with ulcer)
Constipation
Erythema (redness of the skin)
Female genital tract fistula (passage in genital tract of female)
Frequent bowel movements
Haematochezia (passage of stools containing blood)
Headache (pain in head)

What are the existing conditions these people have? *

Pain: 11 people, 18.64%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 10 people, 16.95%
Stress And Anxiety: 9 people, 15.25%
Immunodeficiency Common Variable: 8 people, 13.56%
Constipation: 7 people, 11.86%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 7 people, 11.86%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 7 people, 11.86%
Depression: 6 people, 10.17%
Dehydration (dryness resulting from the removal of water): 6 people, 10.17%
Headache (pain in head): 6 people, 10.17%

* Approximation only. Some reports may have incomplete information.

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