Cisplatin and Femara drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cisplatin (cisplatin) and Femara (letrozole). Common drug interactions include anxiety among females and exposed bone in jaw among males.

The phase IV clinical study analyzes what interactions people have when they take Cisplatin and Femara. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Cisplatin?

Cisplatin has active ingredients of cisplatin. It is often used in chemotherapy. eHealthMe is studying from 92,837 Cisplatin users. Check the latest studies of Cisplatin.

What is Femara?

Femara has active ingredients of letrozole. It is often used in breast cancer. eHealthMe is studying from 19,630 Femara users. Check the latest studies of Femara.

On Jul, 05, 2026

66 people who take Cisplatin and Femara together, and have interactions are studied.

What are the common drug interactions of Cisplatin and Femara, by gender? *:

female:

Anxiety
Dyspnoea (difficult or laboured respiration)
Osteonecrosis of jaw (death of bone of jaw)
Fatigue (feeling of tiredness)
Vomiting
Arthralgia (joint pain)
Insomnia (sleeplessness)
Sinusitis (inflammation of sinus)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)

male:

Exposed bone in jaw
General physical health deterioration (weak health status)
Gingival infection (gum infection)
Malignant neoplasm progression (cancer tumour came back)
Mediastinal shift (organs and tissues get shifted to the chest cavity earlier was in mediastinum like trachea and heart ,oesophagus)
Metastases to chest wall (cancer spreads to chest wall)
Periodontitis (inflammation of the tissue around the teeth)
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)
Primary sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone)
Respiratory disorder (respiratory disease)

What are the common drug interactions of Cisplatin and Femara, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Anaemia (lack of blood)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Faecaloma (hard mass of fecal matter)
Gastrointestinal perforation (hole in the digestive tract)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Pneumoperitoneum (air or gas in the abdominal (peritoneal) cavity)
Pyrexia (fever)
Small intestinal obstruction (blockage in small intestine)

30-39:

n/a

40-49:

Vomiting
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Anaemia (lack of blood)
Anxiety
Bone disorder
Fatigue (feeling of tiredness)
Metastases to bone (cancer spreads to bone)
Pain
Back pain

50-59:

Anxiety
Infection
Osteonecrosis of jaw (death of bone of jaw)
Osteopenia (a condition where bone mineral density is lower than normal)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Aphasia (damage to the parts of the brain that control language)
Ataxia (loss of full control of bodily movements)
Auricular swelling (swelling in the ear)
Breast cancer metastatic
Cellulitis (infection under the skin)

60+:

Exposed bone in jaw
General physical health deterioration (weak health status)
Gingival infection (gum infection)
Malignant neoplasm progression (cancer tumour came back)
Mediastinal shift (organs and tissues get shifted to the chest cavity earlier was in mediastinum like trachea and heart ,oesophagus)
Metastases to chest wall (cancer spreads to chest wall)
Periodontitis (inflammation of the tissue around the teeth)
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)
Primary sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone)
Respiratory disorder (respiratory disease)

What are the existing conditions these people have? *

Breast Cancer Metastatic: 22 people, 33.33%
Metastases To Bone (cancer spreads to bone): 13 people, 19.70%
Sedation: 6 people, 9.09%
Pain: 6 people, 9.09%
Gastric Ulcer (stomach ulcer): 6 people, 9.09%
Gastric Cancer (stomach cancer): 6 people, 9.09%
Eye Pain: 6 people, 9.09%
Neuropathy Peripheral (surface nerve damage): 5 people, 7.58%
Nausea (feeling of having an urge to vomit): 5 people, 7.58%
Diarrhea: 5 people, 7.58%

* Approximation only. Some reports may have incomplete information.

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