Citicoline and Clopra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Citicoline (citicoline) and Clopra (metoclopramide hydrochloride). Common drug interactions include cerebral infarction among females and acute respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Citicoline and Clopra. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Citicoline?

Citicoline has active ingredients of citicoline. eHealthMe is studying from 508 Citicoline users. Check the latest studies of Citicoline.

What is Clopra?

Clopra has active ingredients of metoclopramide hydrochloride. eHealthMe is studying from 81,430 Clopra users. Check the latest studies of Clopra.



On Jul, 13, 2026

12 people who take Citicoline and Clopra together, and have interactions are studied.

Citicoline and Clopra drug interactions.

What are the common drug interactions of Citicoline and Clopra, by gender? *:

female:

  1. Cerebral infarction (less blood supply to brain resulting tissue damage)
  2. Pain
  3. Pruritus (severe itching of the skin)
  4. Activities of daily living impaired
  5. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  6. Anxiety
  7. Cardiac arrest
  8. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  9. Cholecystitis acute (rapid infection of gallbladder)
  10. Deformity (disfigurement)

male:

  1. Acute respiratory failure
  2. Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
  3. Confusional state
  4. Cardiac arrest
  5. Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
  6. Cardiovascular insufficiency (inadequate functioning of heart)
  7. Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
  8. Encephalopathy (functioning of the brain is affected by some agent or condition)
  9. Hallucination (an experience involving the perception of something not present)
  10. Hypertension (high blood pressure)

What are the common drug interactions of Citicoline and Clopra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Encephalopathy (functioning of the brain is affected by some agent or condition)
  2. Hallucination (an experience involving the perception of something not present)
  3. Hypertension (high blood pressure)
  4. Hypoxia (low oxygen in tissues)
  5. Pulmonary oedema (fluid accumulation in the lungs)
  6. Tachypnoea (a condition of rapid breathing over 20 per minute)
  7. Confusional state
  8. Cardiac arrest
  9. Acute respiratory failure
  10. Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Cerebral infarction (less blood supply to brain resulting tissue damage)
  2. Pruritus (severe itching of the skin)
  3. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  4. Hypersensitivity
  5. Lip swelling
  6. Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

What are the existing conditions these people have? *

  1. Urinary Tract Infection: 1 person, 8.33%
  2. Type 2 Diabetes: 1 person, 8.33%
  3. Cardiac Failure: 1 person, 8.33%
  4. Chest Pain: 1 person, 8.33%
  5. Constipation: 1 person, 8.33%
  6. Craniocerebral Injury (injury to cranium and brain): 1 person, 8.33%
  7. Fungal Infection: 1 person, 8.33%
  8. Hypoalbuminaemia (levels of albumin in blood serum are abnormally low): 1 person, 8.33%
  9. Indigestion: 1 person, 8.33%
  10. Nausea (feeling of having an urge to vomit): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Citicoline and Clopra?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Citicoline and Clopra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Citicoline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Clopra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Citicoline and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Clopra and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on citicoline and metoclopramide hydrochloride (the active ingredients of Citicoline and Clopra, respectively), and Citicoline and Clopra (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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