Clexane and Prolia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clexane (enoxaparin sodium) and Prolia (denosumab). Common drug interactions include musculoskeletal stiffness among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Clexane and Prolia. It is created by eHealthMe based on reports of 90 people who take the same drugs from the FDA, and is updated regularly.

What is Clexane?

Clexane has active ingredients of enoxaparin sodium. eHealthMe is studying from 14,679 Clexane users. Check the latest studies of Clexane.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,388 Prolia users. Check the latest studies of Prolia.

On Jul, 15, 2026

90 people who take Clexane and Prolia together, and have interactions are studied.

What are the common drug interactions of Clexane and Prolia, by gender? *:

female:

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Neuropathy peripheral (surface nerve damage)
Non-cardiac chest pain
Oral candidiasis (fungal infection of mouth)
Oropharyngeal pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Productive cough
Pulmonary thrombosis (scarring in the lungs)
Rash
Rash macular (small, flat red spots)

male:

Depression
Erysipelas (bacterial skin infection)
Platelet count decreased
Prostate cancer
Rash erythematous (redness of the skin)
Sepsis (a severe blood infection that can lead to organ failure and death)
Suture rupture
Venous thrombosis limb (blood clot that forms in a vein in the limb)
Soft tissue disorder (disease of soft tissue)
Leukopenia (less number of white blood cells in blood)

What are the common drug interactions of Clexane and Prolia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Pancreatitis (inflammation of pancreas)

10-19:

n/a

20-29:

n/a

30-39:

Antepartum haemorrhage (bleeding from the vagina during pregnancy from the 24th week)
Blood calcium decreased
Blood parathyroid hormone increased
Blood pressure diastolic increased
Foetal distress syndrome (altered heart rate or rhythm and leading tocompromised blood flow or changes in blood chemistry of foetus)
Foetal growth restriction (poor growth of a baby while in the mother's womb during pregnancy)
Gestational trophoblastic detachment (impaired connection of surrounding layer of foetus nutrition supplying cells in pregnancy)
Maternal exposure during pregnancy (use of substance during pregnancy)
Mitral valve disease (disease of mitral valve of heart)
Oligohydramnios (a condition in pregnancy characterized by a deficiency of amniotic fluid)

40-49:

Abdominal pain
Influenza like illness
Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)

50-59:

Chest discomfort
Chest pain
Confusional state
Constipation
Cough
Decreased appetite
Diarrhoea
Dry mouth
Dry skin
Dysgeusia (disorder of the sense of taste)

60+:

Fall
Impaired healing
Lymphoedema (localized fluid retention and tissue swelling)
Platelet count decreased
Prostate cancer
Sepsis (a severe blood infection that can lead to organ failure and death)
Suture rupture
Venous thrombosis limb (blood clot that forms in a vein in the limb)
Soft tissue disorder (disease of soft tissue)
Leukopenia (less number of white blood cells in blood)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 49 people, 54.44%
Vasculitis (inflammation of a blood vessel or blood vessels): 48 people, 53.33%
Venous Thrombosis Limb (blood clot that forms in a vein in the limb): 45 people, 50.00%
Muscle Aches (muscle pain): 45 people, 50.00%
Temporal Arteritis (inflammation and damage to blood vessels that supply the head area): 15 people, 16.67%
High Blood Pressure: 6 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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