Climara and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Climara (estradiol) and Actos (pioglitazone hydrochloride). Common drug interactions include chronic kidney disease among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Climara and Actos. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Climara?

Climara has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,706 Climara users. Check the latest studies of Climara.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

On Jul, 09, 2026

15 people who take Climara and Actos together, and have interactions are studied.

What are the common drug interactions of Climara and Actos, by gender? *:

female:

Chronic kidney disease
Agitation (state of anxiety or nervous excitement)
Anxiety
Hyperglycaemia (high blood sugar)
Suicidal ideation
Abdominal pain upper
Accident
Adverse drug reaction
Alopecia (absence of hair from areas of the body)
Blood potassium increased

male:

Anaemia (lack of blood)
Anxiety
Stress
Depression
Emotional distress
Fear
Injury
Pain
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)

What are the common drug interactions of Climara and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hyperglycaemia (high blood sugar)
Adverse drug reaction
Costochondritis (chest wall pain)
Dysaesthesia (abnormal sensation)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Menometrorrhagia (a condition in which prolonged or excessive uterine bleeding occurs irregularly and more frequently than normal)
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Myalgia (muscle pain)
Osteonecrosis (death of bone)

50-59:

Anxiety
Depression
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Anaemia (lack of blood)
Chronic kidney disease
Emotional distress
Fear
Injury
Pain

60+:

Abdominal pain upper
Accident
Hair colour changes
Hair disorder
Hypotension (abnormally low blood pressure)
Laboratory test abnormal
Palpitations (feelings or sensations that your heart is pounding or racing)
Alopecia (absence of hair from areas of the body)
Blood potassium increased
Blood urea increased

What are the existing conditions these people have? *

Retinopathy Proliferative (a condition in which very small blood vessels grow from the surface of the retina and damages retina): 3 people, 20.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 20.00%
Thyroid Diseases: 1 person, 6.67%
Stress And Anxiety: 1 person, 6.67%
Stable Angina (a constant chest pain): 1 person, 6.67%
Insomnia (sleeplessness): 1 person, 6.67%
High Blood Pressure: 1 person, 6.67%
Depression: 1 person, 6.67%
Breast Cancer Female: 1 person, 6.67%
Arrhythmias (irregular heartbeat): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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