Climara and Centrum silver drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Climara (estradiol) and Centrum silver (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e). Common drug interactions include breast cancer female among females.

The phase IV clinical study analyzes what interactions people have when they take Climara and Centrum silver. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Climara?

Climara has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,706 Climara users. Check the latest studies of Climara.

What is Centrum silver?

Centrum silver has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 19,997 Centrum silver users. Check the latest studies of Centrum silver.

On Jul, 18, 2026

11 people who take Climara and Centrum silver together, and have interactions are studied.

Climara and Centrum silver drug interactions.

What are the common drug interactions of Climara and Centrum Silver, by gender? *:

female:

Breast cancer female
Breast infection
Arthralgia (joint pain)
Back pain
Blood urine present
Death
Depression
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Gastrointestinal telangiectasia (permanent dilation of pre-existing small blood vessels, creating focal red lesions in gastrointestinal tract)
Headache (pain in head)

male:

n/a

What are the common drug interactions of Climara and Centrum Silver, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Malaise (a feeling of general discomfort or uneasiness)
Anxiety
Depression
Gastrointestinal telangiectasia (permanent dilation of pre-existing small blood vessels, creating focal red lesions in gastrointestinal tract)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Myalgia (muscle pain)
Neuropathy peripheral (surface nerve damage)
Therapeutic response decreased (less preventive response)

60+:

Breast cancer female
Breast infection
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)
Deformity (disfigurement)
Marital problem
Pain
Abdominal pain
Application site rash
Death

What are the existing conditions these people have? *

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 27.27%
Hot Flush (sudden feelings of heat): 3 people, 27.27%
High Blood Cholesterol: 3 people, 27.27%
Depression: 3 people, 27.27%
Cardiac Disorder: 3 people, 27.27%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 18.18%
Weight Loss: 1 person, 9.09%
Sleep Disorder: 1 person, 9.09%
Migraine (headache): 1 person, 9.09%
Menopausal Symptoms: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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