Climara and Gabapentin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Climara (estradiol) and Gabapentin (gabapentin). Common drug interactions include diarrhoea among females.

The phase IV clinical study analyzes what interactions people have when they take Climara and Gabapentin. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Climara?

Climara has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,706 Climara users. Check the latest studies of Climara.

What is Gabapentin?

Gabapentin has active ingredients of gabapentin. It is often used in peripheral neuropathy. eHealthMe is studying from 322,987 Gabapentin users. Check the latest studies of Gabapentin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

84 people who take Climara and Gabapentin together, and have interactions are studied.

Climara and Gabapentin drug interactions.

What are the common drug interactions of Climara and Gabapentin, by gender? *:

female:

Diarrhoea
Fatigue (feeling of tiredness)
Dyspnoea (difficult or laboured respiration)
Hypokalaemia (low potassium)
Syncope (loss of consciousness with an inability to maintain postural tone)
Vomiting
Hypertension (high blood pressure)
Back pain
Cardiac failure congestive
Chest discomfort

male:

n/a

What are the common drug interactions of Climara and Gabapentin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dehydration (dryness resulting from the removal of water)
Hypokalaemia (low potassium)
Nausea (feeling of having an urge to vomit)
Vomiting
Pulmonary hypertension (increase in blood pressure in the lung artery)
Blood creatinine increased
Blood potassium decreased
Blood pressure decreased
Blood sodium decreased
Chest discomfort

40-49:

Weight decreased
Abdominal discomfort
Adverse event
Blood glucose increased
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Chronic kidney disease
Cough
Dyspnoea (difficult or laboured respiration)
Hallucination (an experience involving the perception of something not present)
Renal failure (kidney dysfunction)

50-59:

Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Urinary tract infection
Injection site induration
Injection site pain
Precancerous cells present
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Aortic valve incompetence
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)

60+:

Fatigue (feeling of tiredness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Dehydration (dryness resulting from the removal of water)
Dizziness
Haemorrhage (bleeding)
Hypotension (abnormally low blood pressure)
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Skin irritation
Aptyalism (deficiency or absence of saliva)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 12 people, 14.29%
Fibromyalgia (a long-term condition which causes pain all over the body): 9 people, 10.71%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 8 people, 9.52%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 9.52%
High Blood Cholesterol: 8 people, 9.52%
Depression: 7 people, 8.33%
Psoriasis (immune-mediated disease that affects the skin): 5 people, 5.95%
High Blood Pressure: 5 people, 5.95%

* Approximation only. Some reports may have incomplete information.

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