Climara and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Climara (estradiol) and Profen (ibuprofen). Common drug interactions include intentional self-injury among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Climara and Profen. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Climara?

Climara has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,706 Climara users. Check the latest studies of Climara.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

On Jul, 13, 2026

67 people who take Climara and Profen together, and have interactions are studied.

What are the common drug interactions of Climara and Profen, by gender? *:

female:

Intentional self-injury
Laceration (tearing of soft body tissue)
Rigors (an episode of shaking or exaggerated shivering)
Road traffic accident
Suicide attempt
Tremor (trembling or shaking movements in one or more parts of your body)
Breast cancer
Breast cancer female
Cough
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)

male:

Dizziness
Adenoma benign (non-cancerous tumour -secreting)
Completed suicide (act of taking one's own life)
Cough
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Headache (pain in head)

What are the common drug interactions of Climara and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cholecystitis chronic (long lasting infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gallbladder disorder
Anxiety
Influenza
Panic attack

30-39:

Intestinal perforation (complete penetration of the wall of the intestine)
Road traffic accident
Constipation
Dyspnoea (difficult or laboured respiration)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Adenoma benign (non-cancerous tumour -secreting)
Anaphylactic reaction (serious allergic reaction)
Breast cancer
Breast cancer metastatic
Breast pain

40-49:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Headache (pain in head)
Vomiting
Influenza
Nausea (feeling of having an urge to vomit)
Insomnia (sleeplessness)
Sinusitis (inflammation of sinus)
Depression
Drug ineffective
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)

50-59:

Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Pruritus (severe itching of the skin)
Rectal haemorrhage (bleeding from anus)
Sinus headache (headache caused by sinus infections)
Spinal osteoarthritis (joint cartilage loss in spine)
Chronic kidney disease
Depression
Breast pain
Breast swelling
Radiation skin injury

60+:

Breast cancer female
Arteriosclerosis (thickening and hardening of arteries)
Cervical dysplasia (abnormal changes in the cells on the surface of the cervix)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Abdominal pain upper
Actinic keratosis (skin disease due to sun exposure)
Alveolitis (inflammation in the socket of a tooth)
Application site rash
Application site reaction
Arterial stent insertion

What are the existing conditions these people have? *

Stress And Anxiety: 12 people, 17.91%
Depression: 9 people, 13.43%
Bipolar Disorder (mood disorder): 7 people, 10.45%
Sleep Disorder: 6 people, 8.96%
Anger: 5 people, 7.46%
Thyroid Diseases: 4 people, 5.97%
Menopause (end of monthly cycles in women): 4 people, 5.97%
Hypersensitivity: 4 people, 5.97%
High Blood Cholesterol: 4 people, 5.97%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.97%

* Approximation only. Some reports may have incomplete information.

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