Clonazepam and Cotrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clonazepam (clonazepam) and Cotrim (sulfamethoxazole; trimethoprim). Common drug interactions include anti-hbs antibody positive among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Clonazepam and Cotrim. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Clonazepam?

Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 146,270 Clonazepam users. Check the latest studies of Clonazepam.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

On Jul, 19, 2026

61 people who take Clonazepam and Cotrim together, and have interactions are studied.

Clonazepam and Cotrim drug interactions.

What are the common drug interactions of Clonazepam and Cotrim, by gender? *:

female:

Anti-hbs antibody positive
Epstein-barr virus associated lymphoproliferative disorder (lymphocytes are produced in excessive quantities associated with epstein-barr virus)
Hepatitis b core antigen positive
Abdominal pain
Death
Rib fracture
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Vomiting
Venoocclusive liver disease (small veins in the liver are obstructed)
Anal prolapse (protrusion of rectal tissue through the anus to the exterior of the body)

male:

Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Bk virus infection
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Conjunctival haemorrhage (bleeding underneath the conjunctiva)
Cystitis haemorrhagic (blood in the urine and painful voiding)
Cytomegalovirus infection
Dehydration (dryness resulting from the removal of water)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Memory impairment

What are the common drug interactions of Clonazepam and Cotrim, by age (0-1 to 60+)? *:

0-1:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
Agitation neonatal (people with depression, obsessive-compulsive disorder, post viral fatigue syndrome, schizophrenia, bipolar i disorder)
Feeling jittery

2-9:

Capillary permeability increased (increased ability of small blood vessels to pass fluid in and out)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Drug ineffective
Renal failure (kidney dysfunction)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Anaphylactic reaction (serious allergic reaction)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Hypotension (abnormally low blood pressure)
Renal impairment (severely reduced kidney function)

10-19:

n/a

20-29:

n/a

30-39:

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Sudden death
Venoocclusive liver disease (small veins in the liver are obstructed)
Angiopathy (generic term for a disease of the blood vessels)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis (infection of gallbladder)
Diabetic complication
Pancreatitis (inflammation of pancreas)
Pancreatitis acute (sudden inflammation of pancreas)
Pancreatitis chronic (chronic inflammation of pancreas)

40-49:

Bk virus infection
Cystitis haemorrhagic (blood in the urine and painful voiding)
Cytomegalovirus infection
Dehydration (dryness resulting from the removal of water)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Hypotension (abnormally low blood pressure)
Mucosal inflammation (infection of mucous membrane)
Sepsis (a severe blood infection that can lead to organ failure and death)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Pyrexia (fever)

50-59:

Cardiogenic shock (inadequate circulation of blood)
Cough
Drug hypersensitivity
Drug intolerance (drug sensitivity)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Insomnia (sleeplessness)
Liver disorder (liver diseases)
Lung disorder (lung disease)

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bradycardia (abnormally slow heart action)
Anaemia (lack of blood)
Colon cancer
Mitral valve incompetence (inefficient heart valve)
Mitral valve prolapse (heart's mitral valve doesn't work well)
Multiple injuries
Pain
Blood pressure increased
Cardiac disorder

What are the existing conditions these people have? *

High Blood Pressure: 14 people, 22.95%
Bone Marrow Conditioning Regimen: 11 people, 18.03%
Pain: 10 people, 16.39%
Infection: 8 people, 13.11%
Depression: 8 people, 13.11%
Insomnia (sleeplessness): 7 people, 11.48%
Diarrhea: 6 people, 9.84%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 6 people, 9.84%
Allergies: 6 people, 9.84%
Cytomegalovirus Test Positive: 6 people, 9.84%

* Approximation only. Some reports may have incomplete information.

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