Clonazepam and Dipyrone drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Clonazepam (clonazepam) and Dipyrone (metamizole). Common drug interactions include blood glucose increased among females and drug ineffective among males.
The phase IV clinical study analyzes what interactions people have when they take Clonazepam and Dipyrone. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.
What is Clonazepam?
Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 146,270 Clonazepam users. Check the latest studies of Clonazepam.
What is Dipyrone?
Dipyrone has active ingredients of metamizole. eHealthMe is studying from 1,876 Dipyrone users. Check the latest studies of Dipyrone.
33 people who take Clonazepam and Dipyrone together, and have interactions are studied.

What are the common drug interactions of Clonazepam and Dipyrone, by gender? *:
female:
- Blood glucose increased
- Blood lactic acid increased
- Blood pressure decreased
- Blood triglycerides increased
- Breast enlargement
- Chest discomfort
- Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
- Colitis (inflammation of colon)
- Contusion (a type of hematoma of tissue in which capillaries)
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
male:
- Drug ineffective
- Cardiogenic shock (inadequate circulation of blood)
- Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
- Dry skin
- Essential tremor
- Hypertensive crisis
- Hypertriglyceridaemia (excess of triglycerides in the blood)
- Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
- Insomnia (sleeplessness)
- Large intestine perforation (hole in large intestine)
What are the common drug interactions of Clonazepam and Dipyrone, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
- Fungaemia (fungi circulate in the blood)
10-19:
- Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
- Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
- Ventricular hypokinesia (muscle of one's heart does not contract as much as most peoples' hearts do)
20-29:
- Drug ineffective
- Headache (pain in head)
- Heart rate increased
- Nervousness
- Skin discolouration (change of skin colour)
30-39:
- Aggression
- Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
- Blood prolactin increased
- Drug ineffective
- Psychiatric decompensation (worsening of symptoms to the state of a serious mental disorder)
40-49:
- Pain
- Vomiting
- Fatigue (feeling of tiredness)
- Influenza like illness
- Headache (pain in head)
- Abasia (inability to walk)
- Asthenia (weakness)
- Chills (felling of cold)
- Influenza
- Labyrinthitis (inflammation of the labyrinth or inner ear)
50-59:
- Skin exfoliation (removal of the oldest dead skin cells)
- Somnolence (a state of near-sleep, a strong desire for sleep)
- Spinal pain (pain in spine)
- Swelling
- Tachycardia (a heart rate that exceeds the range of 100 beats/min)
- Throat tightness
- Tibia fracture (fracture of lower leg bone)
- Tremor (trembling or shaking movements in one or more parts of your body)
- Urinary tract infection
- Weight increased
60+:
- Anaemia (lack of blood)
- Hypertension (high blood pressure)
- Blood pressure decreased
- Blood triglycerides increased
- Cataract (clouding of the lens inside the eye)
- Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
- Contusion (a type of hematoma of tissue in which capillaries)
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
- Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
- Dental caries
What are the existing conditions these people have? *
- Pain: 7 people, 21.21%
- Nausea (feeling of having an urge to vomit): 6 people, 18.18%
- Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 18.18%
- Headache (pain in head): 5 people, 15.15%
- Insomnia (sleeplessness): 4 people, 12.12%
- High Blood Pressure: 4 people, 12.12%
- Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 12.12%
- Dizziness: 3 people, 9.09%
- Fever: 3 people, 9.09%
- Sleep Disorder: 3 people, 9.09%
* Approximation only. Some reports may have incomplete information.
Do you take Clonazepam and Dipyrone?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Clonazepam (146,270 reports)
- Dipyrone (1,876 reports)
Browse all drug interactions of Clonazepam and Dipyrone:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Clonazepam:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Dipyrone:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Clonazepam and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Dipyrone and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
- Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
- McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
- McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
- Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
- McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on clonazepam and metamizole (the active ingredients of Clonazepam and Dipyrone, respectively), and Clonazepam and Dipyrone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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