Clonazepam and Otrexup drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clonazepam (clonazepam) and Otrexup (methotrexate). Common drug interactions include injection site haemorrhage among females and cough among males.

The phase IV clinical study analyzes what interactions people have when they take Clonazepam and Otrexup. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Clonazepam?

Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 146,271 Clonazepam users. Check the latest studies of Clonazepam.

What is Otrexup?

Otrexup has active ingredients of methotrexate. eHealthMe is studying from 2,154 Otrexup users. Check the latest studies of Otrexup.

On Aug, 11, 2026

11 people who take Clonazepam and Otrexup together, and have interactions are studied.

Clonazepam and Otrexup drug interactions.

What are the common drug interactions of Clonazepam and Otrexup, by gender? *:

female:

Injection site haemorrhage (bleeding from injection site)
Pruritus (severe itching of the skin)
Abdominal discomfort
Back pain
Blood pressure increased
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Diarrhoea
Diverticular perforation (serious gastrointestinal condition in which the intestine's walls are perforated)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Drug hypersensitivity

male:

Cough
Decreased appetite
Injection site swelling
Lymphadenopathy (disease or enlargement of lymph nodes)
Productive cough
Road traffic accident
Secretion discharge
Urine abnormality
Malaise (a feeling of general discomfort or uneasiness)
White blood cell count decreased

What are the common drug interactions of Clonazepam and Otrexup, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hospitalisation

50-59:

Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Injection site bruising
Injection site haemorrhage (bleeding from injection site)
Injection site pain

60+:

Cough
Decreased appetite
Haemorrhage (bleeding)
Hepatitis (inflammation of the liver)
Hepatitis c
Infection
Injection site haemorrhage (bleeding from injection site)
Injection site swelling
Lymphadenopathy (disease or enlargement of lymph nodes)
Productive cough

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 63.64%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 27.27%
Depression: 3 people, 27.27%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 9.09%
Sleep Disorder: 1 person, 9.09%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 9.09%
Rashes (redness): 1 person, 9.09%
Pain: 1 person, 9.09%
Insomnia (sleeplessness): 1 person, 9.09%
Inflammation: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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