Clonazepam and Zofran odt drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clonazepam (clonazepam) and Zofran odt (ondansetron). Common drug interactions include depression among females and hypertension among males.

The phase IV clinical study analyzes what interactions people have when they take Clonazepam and Zofran odt. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Clonazepam?

Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 146,270 Clonazepam users. Check the latest studies of Clonazepam.

What is Zofran odt?

Zofran odt has active ingredients of ondansetron. It is often used in nausea. eHealthMe is studying from 2,092 Zofran odt users. Check the latest studies of Zofran odt.



On Jul, 07, 2026

37 people who take Clonazepam and Zofran odt together, and have interactions are studied.

Clonazepam and Zofran odt drug interactions.

What are the common drug interactions of Clonazepam and Zofran Odt, by gender? *:

female:

  1. Depression
  2. Osteoporosis (bones weak and more likely to break)
  3. Cardiac disorder
  4. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  5. Foot fracture
  6. Migraine (headache)
  7. Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
  8. Vertigo
  9. Vitamin d deficiency
  10. Osteoarthritis (a joint disease caused by cartilage loss in a joint)

male:

  1. Hypertension (high blood pressure)
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Nervousness
  4. Proteinuria (presence of protein in the urine)
  5. Pyrexia (fever)
  6. Renal impairment (severely reduced kidney function)
  7. Bipolar disorder (mood disorder)
  8. Bone density decreased
  9. Cardiac arrest
  10. Death

What are the common drug interactions of Clonazepam and Zofran Odt, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Cystitis interstitial (unknown cause characterized by bladder pain)
  2. Death
  3. Urinary tract infection

30-39:

  1. Abdominal pain
  2. Back pain
  3. Contusion (a type of hematoma of tissue in which capillaries)
  4. Dizziness
  5. Hereditary angioedema (recurrent episodes of severe swelling)
  6. Impaired healing
  7. Insomnia (sleeplessness)
  8. Joint injury
  9. Muscle spasms (muscle contraction)
  10. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

40-49:

n/a

50-59:

  1. Osteoporosis (bones weak and more likely to break)
  2. Depression
  3. Cardiac disorder
  4. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  5. Foot fracture
  6. Migraine (headache)
  7. Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
  8. Vertigo
  9. Vitamin d deficiency
  10. Osteoarthritis (a joint disease caused by cartilage loss in a joint)

60+:

  1. Fatigue (feeling of tiredness)
  2. Abdominal pain upper
  3. Death
  4. Hallucination, visual (seeing things that aren't there)
  5. Nodule (a growth of abnormal tissue)
  6. Renal failure (kidney dysfunction)
  7. Renal impairment (severely reduced kidney function)
  8. Chills (felling of cold)
  9. Hypertension (high blood pressure)
  10. Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

  1. Multiple Allergies (allergy to multiple agents): 6 people, 16.22%
  2. Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 13.51%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 13.51%
  4. High Blood Pressure: 5 people, 13.51%
  5. Hiv Infection: 5 people, 13.51%
  6. Asthma: 5 people, 13.51%
  7. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 13.51%
  8. Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 5 people, 13.51%
  9. Sleep Disorder: 4 people, 10.81%
  10. Chest Pain: 4 people, 10.81%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Clonazepam and Zofran odt:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Clonazepam:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zofran odt:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Clonazepam and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zofran odt and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on clonazepam and ondansetron (the active ingredients of Clonazepam and Zofran odt, respectively), and Clonazepam and Zofran odt (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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