Clonidine and Codeine sulfate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clonidine (clonidine) and Codeine sulfate (codeine sulfate). Common drug interactions include lumbar spine flattening among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Clonidine and Codeine sulfate. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,645 Clonidine users. Check the latest studies of Clonidine.

What is Codeine sulfate?

Codeine sulfate has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 4,510 Codeine sulfate users. Check the latest studies of Codeine sulfate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

45 people who take Clonidine and Codeine sulfate together, and have interactions are studied.

Clonidine and Codeine sulfate drug interactions.

What are the common drug interactions of Clonidine and Codeine Sulfate, by gender? *:

female:

Lumbar spine flattening (flatten the curve of the lower spine)
Metastases to abdominal cavity (cancer spreads to abdominal cavity)
Metastases to bone (cancer spreads to bone)
Metastases to spine (cancer spreads to spine)
Mouth ulceration (mouth ulcers)
Muscular weakness (muscle weakness)
Nausea (feeling of having an urge to vomit)
Neuralgia (pain in one or more nerves)
Oesophageal pain
Oesophagitis (inflammation of oesophagus)

male:

Death
Cardiac arrest
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bone disorder
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Dental caries
Diplopia (double vision)
Drug hypersensitivity
Fatigue (feeling of tiredness)
Gait disturbance

What are the common drug interactions of Clonidine and Codeine Sulfate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cardiac arrest
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Death
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Poisoning

20-29:

n/a

30-39:

Completed suicide (act of taking one's own life)
Cardiac arrest
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chronic kidney disease
Poisoning
Renal failure (kidney dysfunction)

40-49:

Oropharyngeal pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis of jaw (death of bone of jaw)
Osteopenia (a condition where bone mineral density is lower than normal)
Pain in extremity
Physical disability
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Radiculitis (inflammation of the spinal nerve roots)
Renal cyst (kidney cyst)
Renal disorder (kidney disease)

50-59:

Altered state of consciousness (altered state of mind)
Anaemia (lack of blood)
Anxiety
Aortic dilatation
Arthralgia (joint pain)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bone disorder
Death
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)

60+:

Drug hypersensitivity
Chronic kidney disease
Peripheral swelling
Renal failure (kidney dysfunction)
Diplopia (double vision)
Drug dependence
Fall
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

Bone Loss: 7 people, 15.56%
Thrombosis (formation of a blood clot inside a blood vessel): 6 people, 13.33%
Stress And Anxiety: 6 people, 13.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 13.33%
Ill-Defined Disorder: 6 people, 13.33%
Hypersensitivity: 6 people, 13.33%
Constipation: 6 people, 13.33%
Breast Cancer: 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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