Clonidine and Cotrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clonidine (clonidine) and Cotrim (sulfamethoxazole; trimethoprim). Common drug interactions include pneumonia fungal among females and musculoskeletal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Clonidine and Cotrim. It is created by eHealthMe based on reports of 87 people who take the same drugs from the FDA, and is updated regularly.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,645 Clonidine users. Check the latest studies of Clonidine.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

87 people who take Clonidine and Cotrim together, and have interactions are studied.

What are the common drug interactions of Clonidine and Cotrim, by gender? *:

female:

Pneumonia fungal
Pneumonia haemophilus (haemophilus influenzae type b (hib) bacteria include pneumonia)
Dyspnoea (difficult or laboured respiration)
Kidney transplant rejection
Retroperitoneal haematoma (blood clot between the peritoneum and the posterior abdominal wall)
Asthenia (weakness)
Blood creatinine increased
Blood urea increased
Oral mucosa erosion (erosion of mouth mucous membrane)
Bradycardia (abnormally slow heart action)

male:

Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Pain in extremity
Diarrhoea
Haemolytic uraemic syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypokalaemia (low potassium)
Intra-abdominal haematoma (intra-abdominal localized swelling filled with blood)
Kidney fibrosis (excess fibrous connective tissue in kidney)
Lymphocele (a collection of lymphatic fluid within the body not bordered by epithelial lining)
Renal tubular atrophy (wasting of kidney tubules)

What are the common drug interactions of Clonidine and Cotrim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Complications of transplanted kidney
Diarrhoea
Haemolytic uraemic syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hyperkalaemia (damage to or disease of the kidney)
Hypokalaemia (low potassium)
Intra-abdominal haematoma (intra-abdominal localized swelling filled with blood)
Kidney fibrosis (excess fibrous connective tissue in kidney)
Lymphocele (a collection of lymphatic fluid within the body not bordered by epithelial lining)
Renal tubular atrophy (wasting of kidney tubules)

30-39:

Ureteric anastomosis complication
Bone marrow failure
Angiopathy (generic term for a disease of the blood vessels)
Renal disorder (kidney disease)
Renal transplant
Sepsis (a severe blood infection that can lead to organ failure and death)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

40-49:

Gingival bleeding (bleeding gums)
Haematocrit decreased
Haematuria present (presence of blood in urine due to trauma)
Nephritis interstitial (a kidney condition characterized by swelling in between the kidney tubules)
Rectal haemorrhage (bleeding from anus)
Tooth abscess (pus formation in tooth)
White blood cells urine positive
Anastomotic ulcer haemorrhage
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemoglobin decreased

50-59:

Hyperkalaemia (damage to or disease of the kidney)
Mitral valve incompetence (inefficient heart valve)
Renal failure acute (rapid kidney dysfunction)
Skin cancer
Transplant rejection (a transplant material is not worked)
Vasculitis (inflammation of a blood vessel or blood vessels)
Weight increased
Cardiac failure
Drug toxicity
Lung transplant rejection (failure of lung transplant)

60+:

Erythema (redness of the skin)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Pain
Enterococcal infection
Angiosarcoma (cancer of endothelial-type cells that line vessel walls)
Dyspnoea (difficult or laboured respiration)
General physical health deterioration (weak health status)
Pneumonia fungal
Pneumonia haemophilus (haemophilus influenzae type b (hib) bacteria include pneumonia)
Pyrexia (fever)

What are the existing conditions these people have? *

Diabetes: 30 people, 34.48%
Urinary Tract Infection: 27 people, 31.03%
Osteoporosis (bones weak and more likely to break): 27 people, 31.03%
Heart Disease: 26 people, 29.89%
Cardiac Failure: 26 people, 29.89%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 26 people, 29.89%
Dermatitis Bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid): 26 people, 29.89%
Electrolyte Depletion (act of decreasing electrolyte markedly): 26 people, 29.89%
Bleeding Disorders: 26 people, 29.89%
Local Anaesthesia: 26 people, 29.89%

* Approximation only. Some reports may have incomplete information.

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