Clonidine and Isoptin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clonidine (clonidine) and Isoptin (verapamil hydrochloride). Common drug interactions include bradycardia among females and pruritus among males.

The phase IV clinical study analyzes what interactions people have when they take Clonidine and Isoptin. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,644 Clonidine users. Check the latest studies of Clonidine.

What is Isoptin?

Isoptin has active ingredients of verapamil hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 5,539 Isoptin users. Check the latest studies of Isoptin.

On Jul, 21, 2026

52 people who take Clonidine and Isoptin together, and have interactions are studied.

Clonidine and Isoptin drug interactions.

What are the common drug interactions of Clonidine and Isoptin, by gender? *:

female:

Bradycardia (abnormally slow heart action)
Bradycardia neonatal (sinus rhythm with a heart rate below the normal limit in newborn)
Cardiac murmur (an heart sound in valve abnormality)
Cardiomyopathy (weakening of the heart muscle)
Chest pain
Colitis (inflammation of colon)
Conjunctivitis (pink eye)
Constipation
Corneal erosion (failure of the cornea's outermost layer of epithelial cells to attach to the underlying)
Drug exposure during pregnancy

male:

Pruritus (severe itching of the skin)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Oral mucosa erosion (erosion of mouth mucous membrane)
Rash
Abdominal pain
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Thrombosis (formation of a blood clot inside a blood vessel)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the common drug interactions of Clonidine and Isoptin, by age (0-1 to 60+)? *:

0-1:

Blood gases
Bradycardia neonatal (sinus rhythm with a heart rate below the normal limit in newborn)
Drug exposure during pregnancy
Malaise (a feeling of general discomfort or uneasiness)
Maternal condition affecting foetus (mother condition affecting baby)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Neonatal disorder (disease of neonates)
Neonatal hypotension (low blood pressure in neonate)
Oxygen saturation decreased
Premature baby

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cold sweat
Dizziness
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Restless legs syndrome (a powerful urge to move your legs)
Throat tightness

50-59:

Peripheral ischaemia (impaired circulation to an extremity)
Theft
Androgens decreased
Ankle fracture
Discomfort
Fatigue (feeling of tiredness)
Gait disturbance
Heart rate decreased
Iliac artery stenosis (the abnormal narrowing of a iliac artery)
Pallor

60+:

Pruritus (severe itching of the skin)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Colitis (inflammation of colon)
Lip erosion (peeling off of lip)
Oral mucosa erosion (erosion of mouth mucous membrane)
Pleural effusion (water on the lungs)
Rash
Sweating increased (excess sweating)
Abdominal pain
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 14 people, 26.92%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 13 people, 25.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 13 people, 25.00%
Hypokalemia (low potassium): 12 people, 23.08%
Dyspnea (difficult or laboured breathing): 12 people, 23.08%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 12 people, 23.08%
Alcohol Withdrawal Syndrome: 12 people, 23.08%
Sedation: 11 people, 21.15%
Heart Disease: 11 people, 21.15%
Productive Cough: 10 people, 19.23%

* Approximation only. Some reports may have incomplete information.

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