Clonidine and Roxicet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clonidine (clonidine) and Roxicet (acetaminophen; oxycodone hydrochloride). Common drug interactions include oedema peripheral among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Clonidine and Roxicet. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,644 Clonidine users. Check the latest studies of Clonidine.

What is Roxicet?

Roxicet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 2,254 Roxicet users. Check the latest studies of Roxicet.

On Aug, 12, 2026

34 people who take Clonidine and Roxicet together, and have interactions are studied.

Clonidine and Roxicet drug interactions.

What are the common drug interactions of Clonidine and Roxicet, by gender? *:

female:

Oedema peripheral (superficial swelling)
Skeletal injury (bone and supporting muscle injury)
Sleep talking (talking during sleeping)
Somnambulism (sleep walking)
Tendon injury
Tendonitis (a condition that causes pain and swelling of tendons)
Weight increased
Drug dependence
Joint injury
Back disorder

male:

Chronic kidney disease
Drug dependence
Accident
Aggression
Alopecia (absence of hair from areas of the body)
Anxiety
Atherosclerosis (disorder of the arteries)
Back pain
Bleeding tendency
Bradycardia (abnormally slow heart action)

What are the common drug interactions of Clonidine and Roxicet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)

20-29:

n/a

30-39:

n/a

40-49:

Drug abuse
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Eating disorder
Fall
Fatigue (feeling of tiredness)
Gait disturbance
Hallucination (an experience involving the perception of something not present)
Impaired driving ability
Joint dislocation (a joint position is changed from normal position)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Cellulitis (infection under the skin)
Dyspnoea (difficult or laboured respiration)
Osteomyelitis (infection of bone)
Renal failure acute (rapid kidney dysfunction)
Accident
Aggression
Alopecia (absence of hair from areas of the body)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)

60+:

Chronic kidney disease
Diarrhoea
Migraine (headache)
Muscle weakness (a lack of muscle strength)
Neoplasm malignant (cancer tumour)
Nephrogenic anaemia (anaemia due to kidney disease)
Overdose
Pruritus (severe itching of the skin)
Renal failure (kidney dysfunction)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 38.24%
Insomnia (sleeplessness): 8 people, 23.53%
Depression: 8 people, 23.53%
Restless Leg Syndrome (a powerful urge to move your legs): 6 people, 17.65%
Hypertriglyceridaemia (excess of triglycerides in the blood): 5 people, 14.71%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 5 people, 14.71%
High Blood Cholesterol: 5 people, 14.71%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 5 people, 14.71%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 14.71%
Urinary Tract Infection: 5 people, 14.71%

* Approximation only. Some reports may have incomplete information.

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