Clopidogrel and Zyban drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Clopidogrel (clopidogrel) and Zyban (bupropion hydrochloride). Common drug interactions include cerumen impaction among females and confusion among males.
The phase IV clinical study analyzes what interactions people have when they take Clopidogrel and Zyban. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.
What is Clopidogrel?
Clopidogrel has active ingredients of clopidogrel. It is often used in blood clots. eHealthMe is studying from 92,160 Clopidogrel users. Check the latest studies of Clopidogrel.
What is Zyban?
Zyban has active ingredients of bupropion hydrochloride. It is often used in quit smoking. eHealthMe is studying from 8,029 Zyban users. Check the latest studies of Zyban.
19 people who take Clopidogrel and Zyban together, and have interactions are studied.

What are the common drug interactions of Clopidogrel and Zyban, by gender? *:
female:
- Cerumen impaction
- Chest discomfort
- Chest pain
- Cholecystitis acute (rapid infection of gallbladder)
- Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
- Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
- Confusional state
- Constipation
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
- Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
male:
- Confusion
- Depressed level of consciousness
- Dyspepsia (indigestion)
- Hypertensive encephalopathy (neurological dysfunction induced by malignant hypertension)
- Hypotension (abnormally low blood pressure)
- Nausea (feeling of having an urge to vomit)
- Speech disorder
- Suicidal ideation
- Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
- Vomiting
What are the common drug interactions of Clopidogrel and Zyban, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
- Anxiety
50-59:
- Acidosis (build-up of carbon dioxide in the blood)
- Chronic kidney disease
- Hypervolaemia (abnormally increased volume of blood)
- Renal failure (kidney dysfunction)
- Agitation (state of anxiety or nervous excitement)
- Anxiety
- Bladder infection
- Insomnia (sleeplessness)
- Nausea (feeling of having an urge to vomit)
60+:
- Confusion
- Depressed level of consciousness
- Asthenia (weakness)
- Back pain
- Chest discomfort
- Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
- Constipation
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
- Cough
- Diarrhoea
What are the existing conditions these people have? *
- Depression: 3 people, 15.79%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 15.79%
- Acute Coronary Syndrome (acute chest pain and other symptoms that happen because the heart does not get blood): 2 people, 10.53%
- Stress And Anxiety: 2 people, 10.53%
- Infection: 2 people, 10.53%
- High Blood Pressure: 1 person, 5.26%
- Androgen Deficiency: 1 person, 5.26%
- Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 5.26%
- Cardiac Disorder: 1 person, 5.26%
- Cough: 1 person, 5.26%
* Approximation only. Some reports may have incomplete information.
Do you take Clopidogrel and Zyban?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Clopidogrel (92,160 reports)
- Zyban (8,029 reports)
Browse all drug interactions of Clopidogrel and Zyban:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Clopidogrel:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Zyban:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Clopidogrel and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Zyban and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Lai SW, Lin CL, Liao KF, "Actively using clopidogrel correlates with an increased risk of acute pancreatitis in Taiwan", International journal of cardiology, 2015 Mar .
- Jacob S, Dunn BL, Qureshi ZP, Bandarenko N, Kwaan HC, Pandey DK, McKoy JM, Barnato SE, Winters JL, Cursio JF, Weiss I, "Ticlopidine-, clopidogrel-, and prasugrel-associated thrombotic thrombocytopenic purpura: a 20-year review from the Southern Network on Adverse Reactions (SONAR)", InSeminars in thrombosis and hemostasis, 2012 Jan .
- Frank P, "Ticlopidine-, Clopidogrel-, and Prasugrel-Associated Thrombotic Thrombocytopenic Purpura: A Twenty-Year Review from the Southern Network on Adverse Reactions (SONAR)", , 2012 Jan .
- Lai SW, Lin CL, Liao KF, "Actively using clopidogrel correlates with an increased risk of acute pancreatitis in Taiwan", International journal of cardiology, 2015 Mar .
- Jacob S, Dunn BL, Qureshi ZP, Bandarenko N, Kwaan HC, Pandey DK, McKoy JM, Barnato SE, Winters JL, Cursio JF, Weiss I, "Ticlopidine-, clopidogrel-, and prasugrel-associated thrombotic thrombocytopenic purpura: a 20-year review from the Southern Network on Adverse Reactions (SONAR)", InSeminars in thrombosis and hemostasis, 2012 Jan .
- Frank P, "Ticlopidine-, Clopidogrel-, and Prasugrel-Associated Thrombotic Thrombocytopenic Purpura: A Twenty-Year Review from the Southern Network on Adverse Reactions (SONAR)", , 2012 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on clopidogrel and bupropion hydrochloride (the active ingredients of Clopidogrel and Zyban, respectively), and Clopidogrel and Zyban (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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