Clopra and Emla drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clopra (metoclopramide hydrochloride) and Emla (lidocaine; prilocaine). Common drug interactions include dyspnoea among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Clopra and Emla. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Clopra?

Clopra has active ingredients of metoclopramide hydrochloride. eHealthMe is studying from 81,430 Clopra users. Check the latest studies of Clopra.

What is Emla?

Emla has active ingredients of lidocaine; prilocaine. eHealthMe is studying from 5,276 Emla users. Check the latest studies of Emla.

On Aug, 10, 2026

83 people who take Clopra and Emla together, and have interactions are studied.

What are the common drug interactions of Clopra and Emla, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Acute respiratory distress syndrome
Anaemia (lack of blood)
Back pain
Blood bilirubin increased
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Hypotension (abnormally low blood pressure)
Pneumonia respiratory syncytial viral (respiratory syncytial virus (rsv) is a very common virus that leads to mild, cold-like symptoms in adults and older healthy children)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)

male:

Pyrexia (fever)
Asthenia (weakness)
Diarrhoea
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Headache (pain in head)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Pseudomonas test positive
Secretion discharge
Sputum discoloured

What are the common drug interactions of Clopra and Emla, by age (0-1 to 60+)? *:

0-1:

Acquired methaemoglobinaemia (a condition that results in the formation of an abnormal form of haemoglobin)

2-9:

n/a

10-19:

Acute respiratory distress syndrome
Blood bilirubin increased
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Hypotension (abnormally low blood pressure)
Pneumonia respiratory syncytial viral (respiratory syncytial virus (rsv) is a very common virus that leads to mild, cold-like symptoms in adults and older healthy children)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Paraneoplastic syndrome (symptom that is the consequence of the presence of cancer in the body)
Pruritus (severe itching of the skin)
Rash erythematous (redness of the skin)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)

20-29:

Beta haemolytic streptococcal infection (infection with streptococcus pyogenes, a beta-haemolytic bacterium cause mild to moderately severe respiratory tract, skin, and soft tissue)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Pyrexia (fever)
Waist circumference increased

30-39:

Chest pain
Cough
Night sweats (sweating in night)
Asthenia (weakness)
Chest discomfort
Decreased appetite
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Headache (pain in head)

40-49:

Arthralgia (joint pain)
Pain in extremity
Depression
Hypoaesthesia (reduced sense of touch or sensation)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)
Osteonecrosis of jaw (death of bone of jaw)
Abdominal distension
Abdominal hernia
Abdominal pain

50-59:

Haemorrhage intracranial (bleeding within the skull)
Infusion related reaction
Left ventricular dysfunction
Osteitis (a general term for inflammation of bone)
Pruritus (severe itching of the skin)
Rash
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Kidney infection
Blood pressure decreased
Death

60+:

Dyspnoea (difficult or laboured respiration)
Neutropenia (an abnormally low number of neutrophils)
Cardiac failure congestive
Chronic kidney disease
Dizziness
Fatigue (feeling of tiredness)
Hypoacusis (loss of hearing)
Hypophagia (reduced food intake)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)

What are the existing conditions these people have? *

Pain: 21 people, 25.30%
Nausea (feeling of having an urge to vomit): 19 people, 22.89%
Constipation: 13 people, 15.66%
Cough: 10 people, 12.05%
Sedation: 10 people, 12.05%
Wheezing (a high-pitched whistling sound made while you breath): 9 people, 10.84%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 10.84%
High Blood Pressure: 9 people, 10.84%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 8 people, 9.64%
Migraine (headache): 8 people, 9.64%

* Approximation only. Some reports may have incomplete information.

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