Clopra and Macitentan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clopra (metoclopramide hydrochloride) and Macitentan (macitentan). Common drug interactions include hypokalaemia among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Clopra and Macitentan. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Clopra?

Clopra has active ingredients of metoclopramide hydrochloride. eHealthMe is studying from 81,429 Clopra users. Check the latest studies of Clopra.

What is Macitentan?

Macitentan has active ingredients of macitentan. eHealthMe is studying from 7,371 Macitentan users. Check the latest studies of Macitentan.

On Nov, 03, 2025

14 people who take Clopra and Macitentan together, and have interactions are studied.

Clopra and Macitentan drug interactions.

What are the common drug interactions of Clopra and Macitentan, by gender? *:

female:

Hypokalaemia (low potassium)
Abdominal pain upper
Blood creatinine increased
Blood uric acid increased
Chest discomfort
Gastrointestinal inflammation (inflammation of stomach and intestine)
Herpes zoster
Leukocytosis (increased white blood cells)
Palpitations (feelings or sensations that your heart is pounding or racing)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

male:

Febrile neutropenia (fever with reduced white blood cells)
Abdominal pain
Diarrhoea
Dizziness
Dyspnoea (difficult or laboured respiration)
Fall
Hypoaesthesia (reduced sense of touch or sensation)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)
Rectal haemorrhage (bleeding from anus)

What are the common drug interactions of Clopra and Macitentan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood pressure decreased
Disease progression
Dyspnoea (difficult or laboured respiration)
Pyrexia (fever)
Rash
Respiratory failure (inadequate gas exchange by the respiratory system)

50-59:

Hypokalaemia (low potassium)
Leukocytosis (increased white blood cells)
Palpitations (feelings or sensations that your heart is pounding or racing)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Abdominal pain
Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)
Rectal haemorrhage (bleeding from anus)
Viral upper respiratory tract infection
Febrile neutropenia (fever with reduced white blood cells)
Abdominal pain upper

60+:

Death
Device occlusion
Pneumonia

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 8 people, 57.14%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 5 people, 35.71%
Oedema (fluid collection in tissue): 3 people, 21.43%
Multiple Myeloma (cancer of the plasma cells): 3 people, 21.43%
Mucosal Inflammation (infection of mucous membrane): 3 people, 21.43%
Conjunctivitis (pink eye): 3 people, 21.43%
Diabetes: 3 people, 21.43%
Diarrhea: 3 people, 21.43%
Fever: 3 people, 21.43%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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