Clopra and Makena drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clopra (metoclopramide hydrochloride) and Makena (hydroxyprogesterone caproate). Common drug interactions include premature delivery among females.

The phase IV clinical study analyzes what interactions people have when they take Clopra and Makena. It is created by eHealthMe based on reports of 9 people who take the same drugs from the FDA, and is updated regularly.

What is Clopra?

Clopra has active ingredients of metoclopramide hydrochloride. eHealthMe is studying from 81,429 Clopra users. Check the latest studies of Clopra.

What is Makena?

Makena has active ingredients of hydroxyprogesterone caproate. eHealthMe is studying from 24,292 Makena users. Check the latest studies of Makena.



On Sep, 20, 2025

9 people who take Clopra and Makena together, and have interactions are studied.

Clopra and Makena drug interactions.

What are the common drug interactions of Clopra and Makena, by gender? *:

female:

  1. Premature delivery
  2. Dyspepsia (indigestion)
  3. Peripheral swelling
  4. Pruritus generalised (generalized itching)
  5. Urinary retention (the inability to completely or partially empty the bladder)
  6. Back pain
  7. Cervix haemorrhage uterine (bleeding from cervix in birth canal)
  8. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  9. Dystonia (abnormal muscle tone)
  10. Extrapyramidal disorder (involuntary muscle spasms in the face and neck)

male:

n/a

What are the common drug interactions of Clopra and Makena, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Eye swelling
  2. Injection site erythema (redness at injection site)
  3. Injection site pruritus (severe itching at injection site)
  4. Injection site urticaria (rash of round, red welts on the skin at injection site)
  5. Injection site warmth
  6. Lip swelling
  7. Peripheral swelling
  8. Pruritus generalised (generalized itching)

30-39:

  1. Premature delivery
  2. Dyspepsia (indigestion)
  3. Fungal infection
  4. Hypokalaemia (low potassium)
  5. Urinary retention (the inability to completely or partially empty the bladder)
  6. Back pain
  7. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  8. Migraine (headache)
  9. Pyrexia (fever)
  10. Sinusitis (inflammation of sinus)

40-49:

n/a

50-59:

n/a

60+:

n/a

* Approximation only. Some reports may have incomplete information.

Do you take Clopra and Makena?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Clopra and Makena:

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Browse all side effects of Clopra:

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Browse all side effects of Makena:

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Browse all interactions between Clopra and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Makena and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on metoclopramide hydrochloride and hydroxyprogesterone caproate (the active ingredients of Clopra and Makena, respectively), and Clopra and Makena (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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