Clopra and Mannitol 20% drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clopra (metoclopramide hydrochloride) and Mannitol 20% (mannitol). Common drug interactions include embolism among females and haemorrhagic transformation stroke among males.

The phase IV clinical study analyzes what interactions people have when they take Clopra and Mannitol 20%. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Clopra?

Clopra has active ingredients of metoclopramide hydrochloride. eHealthMe is studying from 81,429 Clopra users. Check the latest studies of Clopra.

What is Mannitol 20%?

Mannitol 20% has active ingredients of mannitol. eHealthMe is studying from 79 Mannitol 20% users. Check the latest studies of Mannitol 20%.

On Oct, 03, 2025

12 people who take Clopra and Mannitol 20% together, and have interactions are studied.

Clopra and Mannitol 20% drug interactions.

What are the common drug interactions of Clopra and Mannitol 20%, by gender? *:

female:

Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Amylase increased
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

male:

Haemorrhagic transformation stroke (haemorrhages develop inside areas of ischemia)
Anticoagulation drug level above therapeutic
Drug ineffective
Electrocardiogram t wave amplitude decreased
Hypovolaemic shock (shock caused by severe blood or fluid loss)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Ventricular extrasystoles (premature cardiac contraction)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the common drug interactions of Clopra and Mannitol 20%, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

40-49:

Blood pressure immeasurable
Drug ineffective
Electrocardiogram t wave amplitude decreased
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Ventricular extrasystoles (premature cardiac contraction)
Asthenia (weakness)
Dyspnoea (difficult or laboured respiration)
Pulmonary embolism (blockage of the main artery of the lung)

50-59:

Febrile neutropenia (fever with reduced white blood cells)
Amylase increased
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

60+:

Anticoagulation drug level above therapeutic
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Hypovolaemic shock (shock caused by severe blood or fluid loss)

What are the existing conditions these people have? *

Nausea And Vomiting: 3 people, 25.00%
Oesophageal Squamous Cell Carcinoma (cancer that begins in flat cells lining the oesophagus): 2 people, 16.67%
Dehydration (dryness resulting from the removal of water): 2 people, 16.67%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 2 people, 16.67%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 8.33%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 1 person, 8.33%
Allergies: 1 person, 8.33%
Cardiac Disorder: 1 person, 8.33%
Cardiac Failure: 1 person, 8.33%
Carnitine Deficiency: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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