Clopra and Multihance drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clopra (metoclopramide hydrochloride) and Multihance (gadobenate dimeglumine). Common drug interactions include muscle twitching among females and nephrogenic systemic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Clopra and Multihance. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Clopra?

Clopra has active ingredients of metoclopramide hydrochloride. eHealthMe is studying from 81,430 Clopra users. Check the latest studies of Clopra.

What is Multihance?

Multihance has active ingredients of gadobenate dimeglumine. eHealthMe is studying from 5,786 Multihance users. Check the latest studies of Multihance.

On Jun, 11, 2026

30 people who take Clopra and Multihance together, and have interactions are studied.

Clopra and Multihance drug interactions.

What are the common drug interactions of Clopra and Multihance, by gender? *:

female:

Muscle twitching
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Nerve injury
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Petechiae (a small red or purple spot caused by bleeding into the skin)
Pruritus generalised (generalized itching)
Rash macular (small, flat red spots)
Skin disorder (skin disease)
Skin plaque (red, scaly patches to appear on the skin)

male:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Cardiac arrest
Myocardial fibrosis (a condition in which the heart's muscle cells are impaired)
Pain
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Subcutaneous nodule
Endocardial fibrosis (cardiac fibrosis refers to an abnormal thickening of the heart valves)
Muscle contracture (a permanent shortening of a muscle)
Skin fibrosis (fibrous tissue formation on skin)
Discomfort

What are the common drug interactions of Clopra and Multihance, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Cardiac arrest
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Metaplasia (change in the type of adult cells in a tissue to a form abnormal for that tissue)
Mobility decreased (ability to move is reduced)
Myocardial fibrosis (a condition in which the heart's muscle cells are impaired)
Pain in extremity
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Skin induration (an abnormally hard spot or area on the skin)
Skin tightness

20-29:

n/a

30-39:

n/a

40-49:

Hypoaesthesia (reduced sense of touch or sensation)
Inflammation
Interstitial lung disease
Joint contracture (a permanent shortening of a muscle or joint)
Joint range of motion decreased (disease of joint movement)
Limb discomfort (discomfort in leg)
Lower extremity mass (mass in lower legs)
Muscle disorder (muscle disease)
Muscle tightness
Muscle twitching

50-59:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Skin induration (an abnormally hard spot or area on the skin)
Skin tightness
Dry skin
Erythema (redness of the skin)
Joint range of motion decreased (disease of joint movement)
Oedema peripheral (superficial swelling)
Pain in extremity
Pruritus (severe itching of the skin)

60+:

Activities of daily living impaired
Anxiety
Insomnia (sleeplessness)
Joint range of motion decreased (disease of joint movement)
Joint stiffness
Mobility decreased (ability to move is reduced)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Pain

What are the existing conditions these people have? *

Joint Pain: 9 people, 30.00%
High Blood Pressure: 8 people, 26.67%
Catheter Related Complication: 8 people, 26.67%
Nuclear Magnetic Resonance Imaging Brain: 7 people, 23.33%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 6 people, 20.00%
Venous Pressure Increased: 4 people, 13.33%
Anaemia (lack of blood): 4 people, 13.33%
Renal Osteodystrophy (a bone disease occurs when the kidneys fail to maintain the proper levels of calcium and phosphorus in the blood): 3 people, 10.00%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 3 people, 10.00%
Headache (pain in head): 3 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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