Clopra and Tpn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clopra (metoclopramide hydrochloride) and Tpn (niacinamide; pyridoxine hydrochloride; tyrosine). Common drug interactions include hyperglycaemia among females and aminoaciduria among males.

The phase IV clinical study analyzes what interactions people have when they take Clopra and Tpn. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Clopra?

Clopra has active ingredients of metoclopramide hydrochloride. eHealthMe is studying from 81,430 Clopra users. Check the latest studies of Clopra.

What is Tpn?

Tpn has active ingredients of niacinamide; pyridoxine hydrochloride; tyrosine. eHealthMe is studying from 1,581 Tpn users. Check the latest studies of Tpn.

On Jul, 11, 2026

51 people who take Clopra and Tpn together, and have interactions are studied.

What are the common drug interactions of Clopra and Tpn, by gender? *:

female:

Hyperglycaemia (high blood sugar)
Hypoxia (low oxygen in tissues)
Malaise (a feeling of general discomfort or uneasiness)
Pain
Pericardial effusion (fluid around the heart)
Somnolence (a state of near-sleep, a strong desire for sleep)
Blood bilirubin increased
Cardiac arrest
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Abdominal distension

male:

Aminoaciduria (presence of amino acids in the urine)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Thrombosis (formation of a blood clot inside a blood vessel)
Vomiting
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Ear infection
Faecal vomiting (faeces in vomiting)
Pain
Parainfluenzae virus infection
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)

What are the common drug interactions of Clopra and Tpn, by age (0-1 to 60+)? *:

0-1:

Ear infection
Faecal vomiting (faeces in vomiting)
Parainfluenzae virus infection
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Rhinovirus infection
Streptococcal infection
Weight decreased
Adenoidal disorder (pharyngeal tonsil disorder)
Bronchial secretion retention
Erosive oesophagitis (acid reflux disease can cause tissue damage in the oesophagus over time)

2-9:

Abdominal pain
Ascites (accumulation of fluid in the abdominal cavity)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Colitis (inflammation of colon)
Cystitis haemorrhagic (blood in the urine and painful voiding)
Fibrin d dimer increased
Generalised oedema (swelling all over the body)
Hepatosplenomegaly (enlargement of both the liver and the spleen)
Hyperglycaemia (high blood sugar)
Hypoxia (low oxygen in tissues)

10-19:

Cardiac arrest
Paraneoplastic syndrome (symptom that is the consequence of the presence of cancer in the body)
Bacterial infection
Blood bilirubin increased
Respiratory failure (inadequate gas exchange by the respiratory system)
Discomfort
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Metaplasia (change in the type of adult cells in a tissue to a form abnormal for that tissue)
Mobility decreased (ability to move is reduced)
Muscle contracture (a permanent shortening of a muscle)

20-29:

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

30-39:

Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Right ventricular failure (right half of the heart fails to work)
Septic shock (shock due to blood infection)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Skin wound
Somnolence (a state of near-sleep, a strong desire for sleep)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Vomiting

40-49:

Alopecia (absence of hair from areas of the body)
Hair colour changes
Hair disorder

50-59:

Aminoaciduria (presence of amino acids in the urine)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Fistula (an abnormal connection or passageway between two)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Neutropenia (an abnormally low number of neutrophils)
Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Abdominal distension
Abnormal faeces (abnormal stool)
Allergic pharyngitis (infection or irritation of the pharynx and/or tonsils due to allergy)
Anxiety

What are the existing conditions these people have? *

Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 14 people, 27.45%
Pain: 10 people, 19.61%
Diarrhea: 9 people, 17.65%
Sepsis (a severe blood infection that can lead to organ failure and death): 8 people, 15.69%
Nausea (feeling of having an urge to vomit): 8 people, 15.69%
Infection: 7 people, 13.73%
Constipation: 5 people, 9.80%
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract): 4 people, 7.84%
High Blood Pressure: 4 people, 7.84%
Swallowing Difficulty: 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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