Clopra and Vimpat drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clopra (metoclopramide hydrochloride) and Vimpat (lacosamide). Common drug interactions include cerebrovascular accident among females and acute prerenal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Clopra and Vimpat. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Clopra?

Clopra has active ingredients of metoclopramide hydrochloride. eHealthMe is studying from 81,430 Clopra users. Check the latest studies of Clopra.

What is Vimpat?

Vimpat has active ingredients of lacosamide. It is often used in epilepsy. eHealthMe is studying from 20,832 Vimpat users. Check the latest studies of Vimpat.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

69 people who take Clopra and Vimpat together, and have interactions are studied.

What are the common drug interactions of Clopra and Vimpat, by gender? *:

female:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Colitis (inflammation of colon)
Coronary artery stenosis (narrowing of coronary artery)
Crying
Decreased appetite
Depression
Electrocardiogram pq interval prolonged
Lobar pneumonia (a form of pneumonia that affects a large and continuous area of the lobe of a lung)
Loss of consciousness
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)

male:

Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Asthenia (weakness)
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Chronic kidney disease
Drug intolerance (drug sensitivity)
Fatigue (feeling of tiredness)
Muscular weakness (muscle weakness)
Myalgia (muscle pain)
Renal failure (kidney dysfunction)
Seasonal allergy (allergic condition due to certain season)

What are the common drug interactions of Clopra and Vimpat, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Asthenia (weakness)
Blood glucose decreased
Blood pressure decreased
Colitis (inflammation of colon)
Coronary artery stenosis (narrowing of coronary artery)
Decreased appetite
Lobar pneumonia (a form of pneumonia that affects a large and continuous area of the lobe of a lung)
Pulmonary oedema (fluid accumulation in the lungs)
Staphylococcus test positive
Respiratory disorder (respiratory disease)

30-39:

White blood cell count decreased
Bruxism (habitual grinding of the teeth, typically during sleep)
Hemianopia (blindness or reduction in vision in one half of the visual field due to damage of the optic pathways in the brain)
Nausea (feeling of having an urge to vomit)
Skin fissures (a crack in the skin)
Thrombocytopenia (decrease of platelets in blood)
Weight increased
Chronic kidney disease
General physical health deterioration (weak health status)
Insomnia (sleeplessness)

40-49:

Dystonia (abnormal muscle tone)
Emotional disorder
Excessive eye blinking (excessive blinking is dry eyes)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Headache (pain in head)
Impaired gastric emptying
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Lip infection (infection of lip)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

50-59:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Blood pressure increased
Body temperature increased
Cardiovascular disorder (heart diseases)
Flatulence (flatus expelled through the anus)
Hyperhidrosis (abnormally increased sweating)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Muscle rigidity (muscle stiffness)

60+:

Renal failure (kidney dysfunction)
Altered state of consciousness (altered state of mind)
Dehydration (dryness resulting from the removal of water)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Sepsis (a severe blood infection that can lead to organ failure and death)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anorectal cellulitis (serious infection that spreads under the rectal skin)
Arthralgia (joint pain)
Atrophy (wasting away of a part of the body)

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 14 people, 20.29%
Nausea (feeling of having an urge to vomit): 10 people, 14.49%
Pain: 8 people, 11.59%
Diarrhea: 8 people, 11.59%
Depression: 7 people, 10.14%
Sleep Disorder: 6 people, 8.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 8.70%
Asthma: 6 people, 8.70%
Stress And Anxiety: 5 people, 7.25%
High Blood Cholesterol: 5 people, 7.25%

* Approximation only. Some reports may have incomplete information.

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