Clotrimazole and Macrodantin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clotrimazole (clotrimazole) and Macrodantin (nitrofurantoin, macrocrystalline). Common drug interactions include pain among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Clotrimazole and Macrodantin. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Clotrimazole?

Clotrimazole has active ingredients of clotrimazole. It is often used in thrush. eHealthMe is studying from 13,947 Clotrimazole users. Check the latest studies of Clotrimazole.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

On Jul, 08, 2026

17 people who take Clotrimazole and Macrodantin together, and have interactions are studied.

Clotrimazole and Macrodantin drug interactions.

What are the common drug interactions of Clotrimazole and Macrodantin, by gender? *:

female:

Pain
Dementia (madness)
Fatigue (feeling of tiredness)
Infection
Nausea (feeling of having an urge to vomit)
Sinusitis (inflammation of sinus)
Skin cancer
Juvenile idiopathic arthritis (a subset of arthritis seen in childhood)
Coxsackie viral infection (coxsackie virus infection)
Fall

male:

Abdominal pain
Aortic valve incompetence
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle spasms (muscle contraction)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pulmonary embolism (blockage of the main artery of the lung)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Speech disorder

What are the common drug interactions of Clotrimazole and Macrodantin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Fatigue (feeling of tiredness)
Pain
Fall
Infusion related reaction
Juvenile idiopathic arthritis (a subset of arthritis seen in childhood)
Nausea (feeling of having an urge to vomit)
Oropharyngeal pain
Back pain
Catheter site pain
Coagulopathy (blood's ability to clot is impaired)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Abdominal pain upper
Adnexa uteri pain
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)
Dysarthria (speech disorder)
Dyspnoea (difficult or laboured respiration)
Haemorrhage subcutaneous (bleeding from skin)
Headache (pain in head)
Hospitalisation
Hypertension (high blood pressure)

60+:

Abdominal pain
Asthenia (weakness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Platelet count decreased
Pulmonary embolism (blockage of the main artery of the lung)
Urinary retention (the inability to completely or partially empty the bladder)
Chest pain
Device related infection
Fall
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 9 people, 52.94%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 3 people, 17.65%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 11.76%
Sinusitis (inflammation of sinus): 1 person, 5.88%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 5.88%
Renal Cell Carcinoma (a kidney cancer): 1 person, 5.88%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 5.88%
Primary Immunodeficiency Syndrome: 1 person, 5.88%
Pain: 1 person, 5.88%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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