Clozapine and Meropenem drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clozapine (clozapine) and Meropenem (meropenem). Common drug interactions include agranulocytosis among females and acute respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Clozapine and Meropenem. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Clozapine?

Clozapine has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 83,728 Clozapine users. Check the latest studies of Clozapine.

What is Meropenem?

Meropenem has active ingredients of meropenem. eHealthMe is studying from 33,295 Meropenem users. Check the latest studies of Meropenem.

On Jul, 13, 2026

58 people who take Clozapine and Meropenem together, and have interactions are studied.

Clozapine and Meropenem drug interactions.

What are the common drug interactions of Clozapine and Meropenem, by gender? *:

female:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Febrile neutropenia (fever with reduced white blood cells)
Anticonvulsant drug level decreased
Blepharospasm (any abnormal contraction or twitch of the eyelid)
Depressed level of consciousness
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Atelectasis (partial or complete collapse of the lung)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Infection

male:

Acute respiratory failure
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Septic shock (shock due to blood infection)
Renal impairment (severely reduced kidney function)
Sepsis (a severe blood infection that can lead to organ failure and death)
Rash
Alanine aminotransferase increased
Aspartate aminotransferase increased
Haemoglobin decreased
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)

What are the common drug interactions of Clozapine and Meropenem, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood creatine phosphokinase increased
Circulatory collapse
Haemoglobin decreased
Large intestine perforation (hole in large intestine)
Malaise (a feeling of general discomfort or uneasiness)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Renal impairment (severely reduced kidney function)

10-19:

Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Ventricular hypokinesia (muscle of one's heart does not contract as much as most peoples' hearts do)

20-29:

Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Adverse reaction
Drug ineffective
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hypereosinophilic syndrome (group of disorders marked by the sustained overproduction of eosinophiles)
Myocarditis (inflammation of heart muscle myocardium)
Polyserositis (general inflammation of serous membranes, with effusion)
Pyrexia (fever)
Renal failure (kidney dysfunction)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)

30-39:

Heparin-induced thrombocytopenia
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Alanine aminotransferase increased
Anaemia (lack of blood)
Application site reaction
Aspartate aminotransferase increased
Bacterial toxaemia (blood contains bacterial toxins)
Blood bilirubin increased
Blood fibrinogen increased
Electrolyte imbalance

40-49:

Diarrhoea
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Plasma cell myeloma (cancer that begins in plasma cells)
Urinary tract infection
Vomiting
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Neutropenia (an abnormally low number of neutrophils)
Rash
Rash macular (small, flat red spots)

50-59:

Acute respiratory failure
Rash
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Overdose
Schizoaffective disorder bipolar type (mental illness featuring schizophrenia and a mood disorder with mania)
Abnormal behaviour
Anticonvulsant drug level decreased
Drug level decreased
Dysphagia (a condition in which swallowing is difficult or painful)

60+:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Febrile neutropenia (fever with reduced white blood cells)
Klebsiella infection
Phlebitis superficial (inflammation of the walls of a vein-superficial)
Pleural effusion (water on the lungs)
Pneumonia
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Sepsis (a severe blood infection that can lead to organ failure and death)
Unresponsive to stimuli
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the existing conditions these people have? *

Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 11 people, 18.97%
Agitation (state of anxiety or nervous excitement): 10 people, 17.24%
Urinary Tract Infection: 8 people, 13.79%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 7 people, 12.07%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 6 people, 10.34%
Type 2 Diabetes: 5 people, 8.62%
Respiratory Tract Infection: 5 people, 8.62%
Glucose Tolerance Impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 5 people, 8.62%
Bipolar Disorder (mood disorder): 5 people, 8.62%
Schizoaffective Disorder Bipolar Type (mental illness featuring schizophrenia and a mood disorder with mania): 4 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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