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Vitamin c and Endep drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vitamin c (l-ascorbic acid) and Endep (amitriptyline hydrochloride). Common drug interactions include decreased appetite among females and general physical health deterioration among males.

The phase IV clinical study analyzes what interactions people have when they take Vitamin c and Endep. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Vitamin c?

Vitamin c has active ingredients of l-ascorbic acid. It is often used in immune response. eHealthMe is studying from 92,472 Vitamin c users. Check the latest studies of Vitamin c.

What is Endep?

Endep has active ingredients of amitriptyline hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 1,302 Endep users. Check the latest studies of Endep.

On Jul, 13, 2026

11 people who take Vitamin c and Endep together, and have interactions are studied.

Vitamin c and Endep drug interactions.

What are the common drug interactions of Vitamin C and Endep, by gender? *:

female:

  1. Decreased appetite
  2. Muscle spasms (muscle contraction)
  3. Rash
  4. Restlessness (not able to rest)
  5. Stress
  6. Syncope (loss of consciousness with an inability to maintain postural tone)
  7. Temperature intolerance (inability to go in temperature)
  8. Abdominal distension
  9. Dyspepsia (indigestion)
  10. Hypoglycaemia (deficiency of glucose in the bloodstream)

male:

  1. General physical health deterioration (weak health status)

What are the common drug interactions of Vitamin C and Endep, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. General physical health deterioration (weak health status)

50-59:

  1. Abdominal distension
  2. Dyspepsia (indigestion)
  3. Hypoglycaemia (deficiency of glucose in the bloodstream)
  4. Vomiting projectile

60+:

  1. Adverse event
  2. Arrhythmia (irregular heartbeat)
  3. Pyrexia (fever)
  4. Vomiting
  5. Decreased appetite
  6. Dehydration (dryness resulting from the removal of water)
  7. Fatigue (feeling of tiredness)
  8. Febrile neutropenia (fever with reduced white blood cells)
  9. Headache (pain in head)
  10. Mucosal inflammation (infection of mucous membrane)

What are the existing conditions these people have? *

  1. Back Pain: 4 people, 36.36%
  2. Multiple Myeloma (cancer of the plasma cells): 2 people, 18.18%
  3. Meniere's Disease (a disorder of the inner ear that can affect hearing and balance to a varying degree): 2 people, 18.18%
  4. Asthma: 2 people, 18.18%
  5. Type 2 Diabetes: 1 person, 9.09%
  6. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 9.09%
  7. Neuropathy Peripheral (surface nerve damage): 1 person, 9.09%
  8. Migraine (headache): 1 person, 9.09%
  9. Cardiac Disorder: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin c and Endep?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Vitamin c and Endep:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vitamin c:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Endep:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vitamin c and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Endep and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on l-ascorbic acid and amitriptyline hydrochloride (the active ingredients of Vitamin c and Endep, respectively), and Vitamin c and Endep (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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