Clozaril and Aricept drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clozaril (clozapine) and Aricept (donepezil hydrochloride). Common drug interactions include dizziness among females and haemoglobin decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Clozaril and Aricept. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Clozaril?

Clozaril has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 65,127 Clozaril users. Check the latest studies of Clozaril.

What is Aricept?

Aricept has active ingredients of donepezil hydrochloride. It is often used in alzheimer's disease. eHealthMe is studying from 24,756 Aricept users. Check the latest studies of Aricept.

On Jul, 16, 2026

70 people who take Clozaril and Aricept together, and have interactions are studied.

What are the common drug interactions of Clozaril and Aricept, by gender? *:

female:

Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)
Electrocardiogram st segment depression
Electrocardiogram t wave inversion
Essential hypertension (primary hypertension)
High density lipoprotein decreased
Hospitalisation
Hyperlipidaemia (presence of excess lipids in the blood)
Low density lipoprotein increased (cholesterol increased in blood)
Lymphocytic leukaemia (a type of cancer in which the bone marrow makes too many lymphocytes)

male:

Haemoglobin decreased
Death
Carcinoma (cancer)
Coma (state of unconsciousness lasting more than six hours)
Drug level increased
Mean cell haemoglobin decreased (less than normal haemoglobin per red blood cell in a sample of blood)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Parkinson's disease
Red cell distribution width increased
Tardive dyskinesia (a disorder that involves involuntary movements)

What are the common drug interactions of Clozaril and Aricept, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hyperhidrosis (abnormally increased sweating)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Leukocytosis (increased white blood cells)
Psychotic disorder

40-49:

Circulatory collapse
Anxiety
Back pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Depression
Drug level increased
Flatulence (flatus expelled through the anus)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Osteomyelitis (infection of bone)

50-59:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Tardive dyskinesia (a disorder that involves involuntary movements)
Type 1 diabetes mellitus
Type 2 diabetes mellitus
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Antipsychotic drug level increased
Confusional state
Hemiparesis (weakness on one side of the body)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)

60+:

Death
Anxiety
Atrioventricular block first degree (heart block first degree)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Confusional state
Diabetes mellitus non-insulin-dependent
Electrocardiogram repolarisation abnormality
Hypophagia (reduced food intake)
Renal failure acute (rapid kidney dysfunction)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)

What are the existing conditions these people have? *

Agitation (state of anxiety or nervous excitement): 5 people, 7.14%
Psychotic Disorder: 4 people, 5.71%
Parkinson's Disease: 4 people, 5.71%
Depression: 4 people, 5.71%
Bipolar Disorder (mood disorder): 4 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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